经支气管镜介入诊疗在儿童原发性气道肿瘤中的应用OA北大核心

Objective To summarize the clinical characteristics of primary airway tumors in children and to evaluate the effectiveness and safety of bronchoscopic interventional diagnosis and treatment for these tumors.Methods This retrospective study included 10 pediatric patients diagnosed with primary airway tumors who were hospitalized at Hunan Children's Hospital between January 2019 and September 2023.Clinical symptoms,imaging findings,pathological results,bronchoscopic interventional treatment methods,and patient outcomes were collected and analyzed.Results Among the 10 patients,there were 6 males and 4 females,with an onset age ranging from 1 month and 16 days to 12 years and 5 months.The duration of symptoms varied from 15 to 180 days.Clinical symptoms included cough(n=7),hoarseness(n=4),stridor(n=3),wheezing(n=3),fever(n=2),and he-moptysis(n=1).The tumor locations were:larynx(n=6,including 4 in supraglottic and epiglottic regions,and 2 in the subglottic region),trachea and bronchi(n=4,including 1 in the trachea,1 in the left main bronchus,1 in the right main bronchus,and 1 in the right middle lobe bronchus).Tumor pathology included subglottic hemangio-ma(n=2),laryngeal papilloma(n=4),adenoma(n=1),mucoepidermoid carcinoma(n=2),and inflammato-ry myofibroblastic tumor(n=1).All patients underwent bronchoscopic diagnosis and treatment.The 2 cases of subglottic hemangioma showed improvement with oral propranolol therapy.The 4 cases of laryngeal papilloma re-quired multiple surgical treatments.One patient with adenoma underwent bronchoscopic intervention and remained recurrence-free during 30 months of follow-up.The 2 cases of mucoepidermoid carcinoma and 1 case of inflamma-tory myofibroblastic biopsy and partial tumor resection,followed by surgical resection.The three patients who un-derwent surgical treatment were followed up for 18,30,and 36 months,respectively,with no severe intraoperative or postoperative complications such as massive hemorrhage and pneumothorax.Conclusions Primary airway tumors in children present with non-specific symptoms,leading to frequent misdiagnoses and missed diagnoses.Bronchoscopic intervention plays a crucial role in obtaining pathological confirmation and serves as a valuable tool in preparing for definitive surgical treatment in cases of malignant airway tumors.