纳秒脉冲电场促进伤口愈合的研究进展OACSTPCD

Wound healing is a complex and dynamic physiological process involving multiple stages of biological responses,including hemostasis,inflammation,proliferation,and remodeling.In recent years,nanosecond pulsed electric field(nsPEF)has garnered significant attention for their potential in cellular and tissue repair,demonstrating promising applications in promoting wound healing.This review systematically summarized the fundamental principles of nsPEF and its mechanisms of influence during the wound healing process,exploring its effects on cell proliferation,migration,angiogenesis,and anti-inflammatory and antibacterial actions,as well as its ability to enhance the uptake of drugs and nutrients through electroporation.Although nsPEF is still in the exploratory stage of clinical application,preliminary results from animal models and clinical trials have shown that it can significantly accelerate the healing of acute and chronic wounds while reducing infection rates.However,further research is needed to address questions regarding the effects of different intensities,frequencies,and durations of electric field exposure on treatment outcomes,as well as the applicability to various wound types and long-term safety.Future studies should focus on optimizing the parameters of nsPEF use and combining it with other treatment methods to achieve personalized treatment plans,thereby improving overall efficacy and safety.