纳秒脉冲电场介导肿瘤电消融的分子生物信号通路OACSTPCD

Nanosecond pulsed electric field(nsPEF)is an emerging electroablation technology that induces tumor cell electroporation,calcium influx,and reactive oxygen species accumulation by applying a high-intensity electric field in an extremely short duration.This paper summarized the mechanisms of nsPEF in tumor ablation,particularly its specific effects at the cellular and molecular levels.Research indicated that nsPEF induced tumor cell death through various pathways,including intrinsic and extrinsic apoptosis,necrosis,autophagy,and immune response pathways,thereby enhancing anti-tumor immune reactions.Despite the potential of nsPEF in tumor treatment,its application faces challenges such as the need for further elucidation of its mechanisms,optimization of parameters,and improvement of treatment strategies.Future research should continue to explore the application of nsPEF in different types of tumors and integrate it with other treatment modalities to develop more comprehensive and personalized therapeutic approaches,thereby enhancing its clinical efficacy and safety.