Exploring the Yin-Yang equilibrium:Jin Gui Shen Qi Pills as a treatment for chronic glomerulonephritisOA

Chronic glomerulonephritis is a renal disease characterized by multifactorial etiology,intricate pathogenesis,and persistent inflammatory response involving macrophages as the principal inflammatory cells.The polarization of macrophages into anti-inflammatory and pro-inflammatory phenotypes necessitates a delicate balance in chronic glomerulonephritis,mirroring the concept of yin-yang equilibrium in Chinese medicine theory pertaining to kidney function.Clinical studies have demonstrated the efficacy of Jin Gui Shen Qi Pills in the treatment of chronic glomerulonephritis,while pharmacological studies have revealed that the formula theory of Jin Gui Shen Qi Pills can modulate macrophage polarization and enhance the equilibrium between anti-inflammatory and pro-inflammatory activities.This article examines the correlation between the formula theory of Jin Gui Shen Qi Pills and the concepts of yin and yang by utilizing theoretical analysis,as well as incorporating findings from contemporary clinical and experimental studies.The study aims to elucidate the connection between the pathogenesis of chronic glomerulonephritis and the polarization of macrophages,ultimately proposing that Jin Gui Shen Qi Pills can potentially regulate macrophage polarization as a treatment for chronic glomerulonephritis.The proposition is made that Jin Gui Shen Qi Pills plays a regulatory role in macrophage polarization for the treatment of chronic glomerulonephritis,aiming to establish equilibrium between anti-inflammatory and pro-inflammatory responses,thereby offering a novel approach for integrating Chinese and Western medicine in the clinical management of chronic glomerulonephritis.