Combined therapy of a case of multiple venous malformation with FLT4 gene mutationOA
As the study of vascular anomalies progresses,it is imperative for plastic surgeons to individualize their in-depth research and practice to develop more effective and personalized treatment plans.Recent advancements in genome sequencing technology have highlighted the importance of vascular endothelial growth factor(VEGF)and its receptor(VEGFR)in the formation and alteration of vascularity.However,definitive reports regarding mutations associated with this locus and treatment experiences remain scarce.Herein,we report a clinical case of multiple venous malformations with mutations in VEGFR3(FLT4).We implemented a comprehensive approach,including local lesion excision of the left foot and trunk,oral propranolol administration,and local physiotherapy.After two years of follow-up,the patient’s left foot venous malformation did not recur,and he expressed satisfaction with the outcomes of the combined therapy.This case offers valuable insights into the clinical management of this mutant type and similar presentations of multiple venous malformations.
Yang Yang;Ningyuan Gao;Ming Ren;Lu Wang;Zixu Gao;Rongkui Luo;Chuanyuan Wei;Jianying Gu
Department of Plastic and Reconstructive Surgery,Zhongshan Hospital of Fudan University,Shanghai,200032,ChinaDepartment of Plastic and Reconstructive Surgery,Zhongshan Hospital of Fudan University,Shanghai,200032,ChinaDepartment of Plastic and Reconstructive Surgery,Zhongshan Hospital of Fudan University,Shanghai,200032,ChinaDepartment of Plastic and Reconstructive Surgery,Zhongshan Hospital of Fudan University,Shanghai,200032,ChinaDepartment of Plastic and Reconstructive Surgery,Zhongshan Hospital of Fudan University,Shanghai,200032,ChinaDepartment of Pathology,Zhongshan Hospital of Fudan University,Shanghai,200032,ChinaDepartment of Plastic and Reconstructive Surgery,Zhongshan Hospital of Fudan University,Shanghai,200032,ChinaDepartment of Pathology,Zhongshan Hospital of Fudan University,Shanghai,200032,China
医药卫生
Multiple venous malformationsWhole-exome sequencingFLT4 mutations
《Chinese Journal of Plastic and Reconstructive Surgery》 2025 (1)
P.18-22,5
supported by the National Natural Science Foundation of China(grant no.82272891).
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