Paroxetine alleviates dendritic cell and T lymphocyte activation via GRK2-mediated PI3K-AKT signaling in rheumatoid arthritisOACSCDCSTPCD
Paroxetine alleviates dendritic cell and T lymphocyte activation via GRK2-mediated PI3K-AKT signaling in rheumatoid arthritis
Tingting Liu;Wenjing Zhou;Chao Tan;Xianli Wang;Wei Wei;Chao Jin;Jing Sun;Lina Zhu;Chun Wang;Feng Xiao;Xiaochang Liu;Liying Lv;Xiaoke Yang
Department of Pharmacy,The First Affiliated Hospital of Anhui Medical University,Hefei,Anhui 230022,China||The Grade 3 Pharmaceutical Chemistry Laboratory of State Administration of Traditional Chinese Medicine,Hefei,Anhui 230022,ChinaDepartment of Pharmacy,The First Affiliated Hospital of Anhui Medical University,Hefei,Anhui 230022,China||The Grade 3 Pharmaceutical Chemistry Laboratory of State Administration of Traditional Chinese Medicine,Hefei,Anhui 230022,ChinaDepartment of Pharmacy,The First Affiliated Hospital of Anhui Medical University,Hefei,Anhui 230022,China||The Grade 3 Pharmaceutical Chemistry Laboratory of State Administration of Traditional Chinese Medicine,Hefei,Anhui 230022,ChinaDepartment of Pharmacy,The Obstetrics and Gynecology Hospital of Fudan University,Shanghai 200090,ChinaInstitute of Clinical Pharmacology,Anhui Medical University,The Key Laboratory of Anti-inflammatory and Immune Medicine,Ministry of Education,Anhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine,Hefei,Anhui 230032,ChinaDepartment of Pharmacy,Sir Run Run Shaw Hospital,School of Medicine,Zhejiang University,Hangzhou,Zhejiang 310016,ChinaDepartment of Pharmacy,The First Affiliated Hospital of Anhui Medical University,Hefei,Anhui 230022,China||The Grade 3 Pharmaceutical Chemistry Laboratory of State Administration of Traditional Chinese Medicine,Hefei,Anhui 230022,ChinaDepartment of Obstetrics and Gynecology,The First Affiliated Hospital of Anhui Medical University,Hefei,Anhui 230022,ChinaInstitute of Clinical Pharmacology,Anhui Medical University,The Key Laboratory of Anti-inflammatory and Immune Medicine,Ministry of Education,Anhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine,Hefei,Anhui 230032,ChinaInstitute of Clinical Pharmacology,Anhui Medical University,The Key Laboratory of Anti-inflammatory and Immune Medicine,Ministry of Education,Anhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine,Hefei,Anhui 230032,ChinaDepartment of Gastroenterology,The First Affiliated Hospital of Anhui Medical University,Hefei,Anhui 230022,ChinaDepartment of Clinical Laboratory,The First Affiliated Hospital of Anhui Medical University,Hefei,Anhui 230022,ChinaDepartment of Rheumatology and Immunology,The First Affiliated Hospital of Anhui Medical University,Hefei,Anhui 230022,China
G protein-coupled receptor kinase 2ParoxetineDendritic cellT lymphocytePI3K-AKT-mTOR axisRheumatoid arthritis
G protein-coupled receptor kinase 2ParoxetineDendritic cellT lymphocytePI3K-AKT-mTOR axisRheumatoid arthritis
《中华医学杂志（英文版）》 2025 (4)
441-451,11
This work was supported by the National Natural Science Foundation of China(No.81903622),the Natural Science Foundation of Universities of Anhui Province(No.2023AH053290),the Research Fund of Anhui Institute of Translational Medicine(No.2022zhyx-C30),the Open Fund of Key Laboratory of Anti-inflammatory and Immune Medicine,Ministry of Education,P.R.China(Anhui Medical University)(No.KFJJ-2023-03),the Phar-maceutical Innovation Fund of Anhui Medical University(No.YXCX202205),the Nature Science Foundation of Anhui Province of China(No.1908085QH378),the Postgraduate Innovation Research and Practice Program of Anhui Medical University(No.YJS20230060),and the Special Clinical Research Project of Shanghai Municipal Health Commission(No.202140065).
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