Artificial intelligence-enabled discovery of a RIPK3 inhibitor with neuroprotective effects in an acute glaucoma mouse modelOACSCDCSTPCD
Artificial intelligence-enabled discovery of a RIPK3 inhibitor with neuroprotective effects in an acute glaucoma mouse model
Xing Tu;Zixing Zou;Jiahui Li;Simiao Zeng;Zhengchao Luo;Gen Li;Yuanxu Gao;Kang Zhang
Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sciences,Guangzhou,Guangdong 510530,China||Guangzhou National Laboratory,Guangzhou International Bio Island,Guangzhou,Guangdong 510530,China||State Key Laboratory of Ophthalmology,Zhongshan Ophthalmic Center,Sun Yat-sen University,Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science,Guangzhou,Guangdong 510623,China||University of Chinese Academy of Sciences,Beijing 100049,ChinaGuangzhou National Laboratory,Guangzhou International Bio Island,Guangzhou,Guangdong 510530,ChinaGuangzhou National Laboratory,Guangzhou International Bio Island,Guangzhou,Guangdong 510530,China||State Key Laboratory of Ophthalmology,Zhongshan Ophthalmic Center,Sun Yat-sen University,Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science,Guangzhou,Guangdong 510623,China||Guangzhou Women and Children's Medical Center,Guangzhou Medical University,Guangzhou,Guangdong 510623,ChinaGuangzhou National Laboratory,Guangzhou International Bio Island,Guangzhou,Guangdong 510530,China||State Key Laboratory of Ophthalmology,Zhongshan Ophthalmic Center,Sun Yat-sen University,Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science,Guangzhou,Guangdong 510623,China||Guangzhou Women and Children's Medical Center,Guangzhou Medical University,Guangzhou,Guangdong 510623,ChinaDepartment of Big Data and Biomedical AI,College of Future Technology,Peking University,Beijing 100871,ChinaGuangzhou Women and Children's Medical Center,Guangzhou Medical University,Guangzhou,Guangdong 510623,ChinaGuangzhou National Laboratory,Guangzhou International Bio Island,Guangzhou,Guangdong 510530,China||Institute for Artificial Intelligence in Medicine and Faculty of Medicine,Macau University of Science and Technology,Macao Special Administrative Region 999078,ChinaGuangzhou National Laboratory,Guangzhou International Bio Island,Guangzhou,Guangdong 510530,China||State Key Laboratory of Ophthalmology,Zhongshan Ophthalmic Center,Sun Yat-sen University,Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science,Guangzhou,Guangdong 510623,China||Institute for Artificial Intelligence in Medicine and Faculty of Medicine,Macau University of Science and Technology,Macao Special Administrative Region 999078,China
Virtual screeningAI modelPANoptosisacute ocular hypertensionHG9-91-01Glucoma
Virtual screeningAI modelPANoptosisacute ocular hypertensionHG9-91-01Glucoma
《中华医学杂志（英文版）》 2025 (2)
172-184,13
The study was supported by grants from the Guangzhou National Laboratory(No.YW-SLJC0201),and Macao Young Scholar Program(No.AM2023024).
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