益生菌在重症急性胰腺炎相关性肺损伤治疗中的研究进展OA

Severe acute pancreatitis-associated lung injury(SAP-LI)is an early complication of acute pancreatitis,characterized by changes in gut microbiota in the early stages.Due to the bidirectional communication between the intestine and lungs,intestinal bacteria and their metabolites lead to the release of a large number of inflammatory factors,further exacerbating lung tissue damage.Probiotics are used in clinical practice for the protection and treatment of intestinal barrier function in various critical diseases,reducing the translocation of intestinal pathogenic bacteria to the lungs through blood circulation and lymphatic pathways,inhibiting the release of inflammatory factors,and providing great help in reducing lung injury.This article reviews the pathophysiological mechanisms of SAP-LI,the biological effects of probiotics,the impact of probiotics on gut microbiota balance,the gut lung axis,immune regulation,and the potential role of probiotics in SAP-LI treatment.