NLRP3炎症小体介导的细胞焦亡在心肌纤维化中的作用及中药调控的研究进展OA
Research progress on the role of cell pyroptosis mediated by NLRP3 inflammatory corpuscles in myocardial fibrosis and the regulation of traditional Chinese medicine
细胞焦亡作为一种炎症性细胞死亡方式,在心脏炎症反应发生发展过程中的作用已成为当下的研究热点.大量研究发现,心肌纤维化(MF)与NOD样受体热蛋白结构域相关蛋白 3(NLRP3)炎症小体介导的细胞焦亡联系紧密.随着研究的深入,中药在改善心脏结构及功能、抑制MF的作用被逐步阐明.基于上述研究,本文综述NLRP3 炎症小体介导的细胞焦亡在MF中的作用机制以及中药基于NLRP3 炎症小体介导的细胞焦亡防治MF的研究进展,以期为MF的防治及中药新药的开发提供新思路.
Cell pyroptosis,as an inflammatory cell death model,has become a current research hotspot in the occurrence and development of cardiac inflammatory response.Many studies have found that myocardial fibrosis(MF)is closely related to pyroptosis mediated by inflammatory corpuscles of NOD-like receptor thermal protein domain associated protein 3(NLRP3).With the deepening of research,the role of traditional Chinese medicine in improving heart structure and function and inhibiting MF has been gradually clarified.Based on the above research,the function mechanism of cell pyroptosis mediated by NLRP3 inflammatory corpuscles in MF and the research progress of traditional Chinese medicine in preventing and treating MF based on cell pyroptosis mediated by NLRP3 inflammatory corpuscles are summarized in this paper,in order to provide new ideas for the prevention and treatment of MF and the development of new traditional Chinese medicine.
王俊森;李欣;宋钦睿;王奕璁;赵红晔
齐齐哈尔医学院基础医学院,黑龙江 齐齐哈尔 161006齐齐哈尔医学院基础医学院,黑龙江 齐齐哈尔 161006齐齐哈尔医学院口腔医学院,黑龙江 齐齐哈尔 161006齐齐哈尔医学院基础医学院,黑龙江 齐齐哈尔 161006齐齐哈尔医学院基础医学院,黑龙江 齐齐哈尔 161006
医药卫生
NOD样受体热蛋白结构域相关蛋白3炎症小体细胞焦亡心肌纤维化中药
NOD-like receptor thermal protein domain associated protein 3 inflammatory corpusclesCell pyroptosisMyocardial fibrosisTraditional Chinese medicine
《中国医药科学》 2025 (2)
16-19,44,5
黑龙江省大学生创新创业训练计划项目(X202311230033).
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