3D打印个性化钛网用于修复严重牙槽骨缺损的临床效果——一项回顾性病例系列研究OA

Objective To analyze the clinical outcomes and accuracy of 3D printing individualized titanium mesh(3D-PITM)in the treatment of severe alveolar bone defects.Methods This study involved 30 patients who underwent 3D-PITM supported guided bone regeneration(3D-PITMs GBR)at the Affiliated Stomatological Hospital of Guangzhou Medical University starting in February 2020.All patients signed informed consent and underwent surgery followed by regular postoperative follow-up.Individualized titanium meshes were fabricated using 3D printing technology,with preoperative virtual design and planning.Patients were followed for 6 to 8 months postoperatively,and clinical outcomes,as well as two-dimensional(2D)and three-dimensional(3D)imaging data,were collected and analyzed.Results Among the 30 patients,4 experienced titanium mesh exposure,yielding an incidence rate of 13.33%(95%CI:4.30%～22.36%).However,none of the patients experienced postoperative infections.During the 6-to 8-month follow-up period,implant sites achieved satisfactory bone augmentation in both horizontal and vertical dimensions.Imaging measurements revealed significant increases in alveolar bone width and height at 6 to 8 months postoperatively compared to preoperative values(P<0.05).Postoperative bone augmentation volume also demonstrated significant improvement(P<0.05).Furthermore,there were no statistically significant differences in alveolar bone changes between preoperative virtual planning and postoperative measurements(immediate and at 6 to 8 months),indicating that 3D-PITM provides predictable bone augmentation outcomes.Conclusion 3D printing individualized titanium mesh effectively supports bone regeneration,achieves a high degree of matching with the defect site,and ensures the stability and effectiveness of newly formed bone.The 3D-PITM technique demonstrates high precision in restoring severe alveolar bone defects.Although complications such as titanium mesh exposure may occur,appropriate management can prevent the adverse impact on subsequent restoration outcomes.3D-PITM is clinically valuable for restoring complex alveolar bone defects,providing reliable postoperative predictions and optimizing surgical planning.