利尿钠肽受体A表达与糖尿病心肌病患者血清NT-proBNP、TGF-β1及心功能相关性OA

Objective To explore the correlations between the expression of natriuretic peptide receptor A and the levels of serum amino terminal brain natriuretic peptide precursor(NT-proBNP)and transforming growth factor(TGF)-β1 and cardiac function in patients with diabetic cardiomyopathy.Methods A total of 120 patients with diabetic cardiomyopathy admitted to the Second Affiliated Hospital of Xi'an Medical College from May 2020 to May 2023 were retrospectively selected as a diabetic cardiomyopathy group,70 healthy people during the same period were selected as a control group,and 50 diabetic patients receiving treatment during the same period were selected as a diabetic group.In the control group,there were 41 males and 29 females,aged(47.16±6.24)years.In the diabetic group,there were 29 males and 21 females,aged(47.62±6.56)years.In the diabetic cardiomyopathy group,there were 62 males and 58 females,aged(48.08±6.88)years.The baseline data,natriuretic peptide receptor A,NT-proBNP,TGF-β1,soluble growth stimulation expression gene 2 protein(sST2),matrix metalloproteinase-2(MMP-2),tissue inhibitor of matrix metalloproteinase-1(TIMP-1),total cholesterol(TC),triacylglycerol(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),left ventricular remodeling index(LVRI),left ventricular posterior wall thickness(LVPW),right ventricular end-systolic volume(RVESV),and cardiac function indicators were compared among the 3 groups.The correlations between the expression of natriuretic peptide receptor A and NT-proBNP,ventricular remodeling,TGF-β 1,myocardial fibrosis,cardiac function,and lipid indexes in 120 patients with diabetic cardiomyopathy were analyzed by Pearson correlation analysis.The statistical methods used were Ftest andx2 test.Results The levels of natriuretic peptide receptor A,NT-proBNP,and TGF-β1 in the diabetic cardiomyopathy group were higher than those in the control group and the diabetic group[0.72±0.21 vs.0.32±0.17 and 0.47±0.21,(1 586.23±300.28)ng/L vs.(1 041.06±284.03)ng/L and(1 313.65±292.16)ng/L,(235.44±30.19)ng/L vs.(221.21±31.06)ng/L and(228.33±30.63)ng/L];the levels of sST2,TIMP-1,TC,TG,LDL-C,LVRI,LVPW,RVESV,and LVEDD were higher than those in the control group and the diabetic group,while the levels of MMP-2,HDL-C,LVEF,E/A,and SV were lower than those in the control group and the diabetic group,with statistically significant differences(all P＜0.05);there were statistically significant differences in the above indexes between the control group and the diabetic group(all P＜0.05).Pearson correlation analysis showed that natriuretic peptide receptor A was positively correlated with the levels of NT-proBNP,TGF-β1,sST2,TIMP-1,TC,TG,LDL-C,LVRI,LVPW,RVESV,and LVEDD in patients with diabetic cardiomyopathy(r=0.432,0.415,0.431,0.418,0.441,0.513,0.475,0.526,0.548,0.519,and 0.356,all P＜0.05),was negatively correlated with the levels of MMP-2,HDL-C,LVEF,E/A,and SV(r=-0.349,-0.482,-0.342,-0.294,and-0.351,all P＜0.05).Conclusion The lower the expression of natriuretic peptide receptor A in patients with diabetic cardiomyopathy,the higher the levels of NT-proBNP and TGF-β1,and the better the cardiac function.