根除幽门螺杆菌与人类免疫缺陷病毒感染者免疫重建的关系研究OA

Objective To investigate the relationship between Helicobacter pylori eradication and immune reconstitution in human immunodeficiency virus(HIV)-infected patients.Methods Data of HIV-infected patients with a positive Helicobacter pylori test(using the 14C-urea breath test)in Guiyang Public Health Clinical Center from April to October 2022 who were on ART and had incomplete immune reconstitution were collected.A total of 60 patients were collected for data.In terms of patient treatment option,Helicobacter pylori was eradicated in 30 patients and not eradicated in another 30 patients.Changes in blood CD4 and CD8 cell counts and percentages,and plasma HIV viral load were compared before and at 3 months,9 months and 15 months after Helicobacter pylori eradication intervention.The changes in blood CD4 and CD8 cell counts and percentages,as well as plasma HIV viral load,between the eradicated and non eradicated groups at corresponding time points were compared.Results At 15 months after the intervention,blood CD4 cell counts and percentages were higher in patients with Helicobacter pylori eradication than those in patients without Helicobacter pylori eradication,with statistically significant differences(P＜0.05).CD8 cell counts and percentages were lower in patients with Helicobacter pylori eradication than those in patients without Helicobacter pylori eradication,with statistically significant differences(P＜0.05).Conclusion Helicobacter pylori eradication promotes the immune reconstitution in HIV-infected patients(incomplete immune reconstitution),and provides a theoretical basis for Helicobacter pylori eradication in HIV-infected patients combined with Helicobacter pylori infection in clinical settings.