阿尔茨海默病患者血清脂联素、Lp-PLA2、IL-17的表达及与认知功能的相关性分析OACSTPCD
Expression of serum adiponectin,Lp-PLA2,IL-17 and correlation analysis with cognitive function in patients with Alzheimer's disease
目的 分析阿尔茨海默病(AD)患者血清脂联素(APN)、脂蛋白相关磷脂酶A2(Lp-PLA2)、白细胞介素17(IL-17)表达水平及其与认知功能的关系.方法 选取泰康同济(武汉)医院神经内科自2020年5月至2022年5月收治的82例AD患者作为观察组,另选同期来我院体检的45名健康者为对照组.AD患者根据临床痴呆评定量表分为轻度组、中度组和重度组,另选简易精神状态量表(MMSE)评估所有受试者的认知功能.比较观察组、对照组以及不同病情患者血清APN、Lp-PLA2、IL-17水平差异.分析AD患者血清APN、Lp-PLA2、IL-17与MMSE评分和病情严重程度的相关性.建立受试者工作特征(ROC)曲线,评估APN、Lp-PLA2、IL-17水平鉴别病情的价值.结果 观察组患者的血清APN水平低于对照组,Lp-PLA2、IL-17水平高于对照组,差异有统计学意义(P＜0.05).APN水平:轻度组＞中度组＞重度组,Lp-PLA2、IL-17水平:轻度组＜中度组＜重度组,差异均有统计学意义(P＜0.05).MMSE评分:对照组＞轻度组＞中度组＞重度组,差异有统计学意义(P＜0.05). MMSE评分与APN呈正相关,与Lp-PLA2、IL-17呈负相关(P＜0.05);病情严重程度与APN呈负相关,与Lp-PLA2、IL-17呈正相关(P＜0.05).血清APN、Lp-PLA2、IL-17单独和联合鉴别轻度与中重度病情的曲线下面积为0.744、0.862、0.834、0.875.结论 AD患者APN、Lp-PLA2、IL-17存在异常表达,与认知功能存在密切相关性,对临床鉴别病情严重程度有一定参考价值.
Objective To analyze the expression levels of serum adiponectin(APN),lipoprotein associated phospholipase A2(Lp-PLA2),interleukin-17(IL-17)and their relationship with cognitive function in patients with Alzheimer's disease(AD).Methods Eighty-two AD patients with income from May 2020 to May 2022 in Neurology Department of Taikang Tongji Hospital were selected as the observation group,and 45 healthy people who came to our hospital for physical examination in the same period were selected as the control group.The patients in AD group were divided into mild group,moderate group and severe group according to their condition with the clinical dementia assessment scale.The cognitive function of the patients was evaluated with the mini mental state scale(MMSE).The serum levels of APN,Lp-PLA2 and IL-17 of all the subjects were measured.The serum levels of APN,Lp-PLA2 and IL-17 in the observation group,the control group and the patients with different disease conditions were compared.The correlation between serum APN,Lp-PLA2,IL-17 and MMSE scores and the severity of the disease in AD patients were analysied.Results The serum APN level in the observation group was lower than that in the control group,and the levels of Lp-PLA2 and IL-17 were higher than that in the control group(P＜0.05).The level of APN in the mild group was higher than that in the moderate group and higher than that in the severe group,the level of Lp-PLA2 and IL-17 in the mild group were lower than those in the moderate group and the severe group,the differences were statistically significant(P＜0.05).The MMSE score of the control group was higher than that of the mild group,the moderate group and the severe group(P＜0.05).MMSE score was positively correlated with APN,negatively correlated with Lp-PLA2 and IL-17(P＜0.05),and the severity of the disease was negatively correlated with APN,positively correlated with Lp-PLA2 and IL-17(P＜0.05).The area under the curve of serum APN,Lp-PLA2 and IL-17 alone or in combination to distinguish mild and moderate severe disease was 0.744,0.862,0.834 and 0.875.Conclusion There are abnormal expressions of APN,Lp-PLA2 and IL-17 in AD patients,which are closely related to cognitive function and have certain reference value for clinical differentiation of the severity of the disease.
张萌;喻中华
430000 武汉,泰康同济(武汉)医院神经内科431600 湖北孝感,汉川市人民医院消化内镜室
阿尔茨海默病脂联素脂蛋白相关磷脂酶A2白细胞介素17认知功能
Alzheimer's diseaseAdiponectinLipoprotein-associated phospholipase A2Interleukin 17Cognitive function
《中华脑科疾病与康复杂志（电子版）》 2023 (6)
358-363,6
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