Epitranscriptomics focuses on the RNA-modification-mediated post-transcriptional regulation of gene expression.The past decade has witnessed tremendous progress in our understanding of the landscapes and biological functions of RNA modifications,as prompted by the emergence of potent analytical approaches.The hematopoietic system provides a lifelong supply of blood cells,and gene expression is tightly controlled during the differentiation of hematopoietic stem cells(HSCs).The dysregulation of gene expression during hematopoiesis may lead to severe disorders,including acute myeloid leukemia(AML).Emerging evidence supports the involvement of the mRNA modification system in normal hematopoiesis and AML pathogenesis,which has led to the development of small-molecule inhibitors that target N6-methyladenosine(m^(6)A)modification machinery as treatments.Here,we summarize the latest findings and our most up-to-date information on the roles of m^(6)A and N7-methylguanine in both physiological and pathological conditions in the hematopoietic system.Furthermore,we will discuss the therapeutic potential and limitations of cancer treatments targeting m^(6)A.
Xiaoxu Zhang;Yanni Ma;Jia Yu;Rui Su;Xiaoshuang Wang;
State Key Laboratory of Common Mechanism Research for Major Diseases,State Key Laboratory for Complex,Severe,and Rare Diseases,Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences/Peking Union Medical College,Beijing 100005,China Department of Systems Biology,Beckman Research Institute of City of Hope,Monrovia,CA 91016,USAState Key Laboratory of Common Mechanism Research for Major Diseases,State Key Laboratory for Complex,Severe,and Rare Diseases,Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences/Peking Union Medical College,Beijing 100005,China The Institute of Blood Transfusion,Chinese Academy of Medical Sciences/Peking Union Medical College,Chengdu,Sichuan 610052,China Key Laboratory of RNA and Hematopoietic Regulation,Chinese Academy of Medical Sciences,Beijing 100005,China Department of Biochemistry and Molecular Biology,Chinese Academy of Medical Sciences,School of Basic Medicine Peking Union Medical College,Beijing 100005,ChinaDepartment of Systems Biology,Beckman Research Institute of City of Hope,Monrovia,CA 91016,USA
临床医学
N6-methyladenosine;N7-methylguanine;Hematopoiesis;Acute myeloid leukemia;Therapeutic target;RNA modifications
《Chinese Medical Journal》 2024 (009)
P.1033-1043 / 11
supported by grants from the National Key Research and Development Program of China(Nos.2019YFA0111700,2019YFA0802603,2019YFA0801800,and 2021YFA0805703);the National Natural Science Foundation of China(Nos.81970154 and 82270192);CAMS Innovation Fund for Medical Sciences(No.2022-I2M-2-001)
10.1097/CM9.0000000000003073
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