Triggering receptor expressed on myeloid cells-1(TREM-1)is a member of the immunoglobulin superfamily.As an amplifier of the inflammatory response,TREM-1 is mainly involved in the production of inflammatory mediators and the regulation of cell survival.TREM-1 has been studied in infectious diseases and more recently in non-infectious disorders.More and more studies have shown that TREM-1 plays an important pathogenic role in kidney diseases.There is evidence that TREM-1 can not only be used as a biomarker for diagnosis of disease but also as a potential therapeutic target to guide the development of novel therapeutic agents for kidney disease.This review summarized molecular biology of TREM-1 and its signaling pathways as well as immune response in the progress of acute kidney injury,renal fibrosis,diabetic nephropathy,immune nephropathy,and renal cell carcinoma.
Yuxi Fan;Ye Xu;Zhi Huo;Hedong Zhang;Longkai Peng;Xin Jiang;Angus W.Thomson;Helong Dai
Department of Immunology,School of Basic Medical Science,Central South University,Changsha,Hunan 410013,China||Department of Kidney Transplantation,Center of Organ Transplantation,The Second Xiangya Hospital of Central South University,Changsha,Hunan 410011,ChinaDepartment of Kidney Transplantation,Center of Organ Transplantation,The Second Xiangya Hospital of Central South University,Changsha,Hunan 410011,China||Medical College of Guangxi University,Nanning,Guangxi 530004,ChinaDepartment of Immunology,School of Basic Medical Science,Central South University,Changsha,Hunan 410013,ChinaDepartment of Kidney Transplantation,Center of Organ Transplantation,The Second Xiangya Hospital of Central South University,Changsha,Hunan 410011,ChinaDepartment of Organ Transplantation,The Fifth Clinical Medical College of Henan University of Chinese Medicine(Zhengzhou People's Hospital),Zhengzhou,Henan 450000,ChinaDepartment of Surgery,Thomas E.Starzl Transplantation Institute,University of Pittsburgh School of Medicine,Pittsburgh,PA 15261,USA
TREM-1;Kidney diseases;Inflammatory response;Biomarker;Therapeutic targets
《中华医学杂志（英文版）》 2024 (014)
1663-1673 / 11
This work was supported by grants from the National Natural Science Foundation of China(Nos.82070776,82270796,82200849,and 82370761),the Science and Technology Innovation Program of Hunan Province(No.2022RC3071),the Natural Science Foundation of Hunan Province(No.2023JJ40872),and the Higher Education Teaching Reform Project of Central South University(No.2023jy110).
10.1097/CM9.0000000000003197
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