Iron is indispensable for the viablility of nearly all living organisms,and it is imperative for cells,tissues,and organisms to acquire this essential metal sufficiently and maintain its metabolic stability for survival.Disruption of iron homeostasis can lead to the development of various diseases.There is a robust connection between iron metabolism and infection,immunity,inflammation,and aging,suggesting that disorders in iron metabolism may contribute to the pathogenesis of arthritis.Numerous studies have focused on the significant role of iron metabolism in the development of arthritis and its potential for targeted drug therapy.Targeting iron metabolism offers a promising approach for individualized treatment of arthritis.Therefore,this review aimed to investigate the mechanisms by which the body maintains iron metabolism and the impacts of iron and iron metabolism disorders on arthritis.Furthermore,this review aimed to identify potential therapeutic targets and active substances related to iron metabolism,which could provide promising research directions in this field.
Dachun Zhuo;Yuexin Yu;Lu Bai;Hejian Zou;Jing Liu;Jiucun Wang;Wenze Xiao;Yulong Tang;Shuai Jiang;Chengchun Geng;Jiangnan Xie;Xiaobei Ma;Qing Zhang;Kunhai Tang
Department of Rheumatology,Shanghai Pudong Hospital,Human Phenome Institute,Zhangjiang Fudan International Innovation Center,Fudan University,Shanghai 200000,China||State Key Laboratory of Genetic Engineering,School of Life Science,Fudan University,Shanghai 200000,ChinaDepartment of Rheumatology,Shanghai Pudong Hospital,Human Phenome Institute,Zhangjiang Fudan International Innovation Center,Fudan University,Shanghai 200000,ChinaDivision of Rheumatology,Huashan Hospital,State Key Laboratory of Genetic Engineering,School of Life Science,Fudan University,Shanghai 200000,China||Institute of Rheumatology,Immunology and Allergy,Allergy and Disease Research Center,Fudan University,Shanghai 200000,ChinaDivision of Rheumatology,Huashan Hospital,State Key Laboratory of Genetic Engineering,School of Life Science,Fudan University,Shanghai 200000,China||Institute of Rheumatology,Immunology and Allergy,Allergy and Disease Research Center,Fudan University,Shanghai 200000,China||Research Unit of Dissecting the Population Genetics and Developing New Technologies for Treatment and Prevention of Skin Phenotypes and Dermatological Diseases(2019RU058),Chinese Academy of Medical Sciences,Beijing 100730,ChinaDepartment of Vascular Surgery,Shanghai Pudong Hospital,Shanghai Key Laboratory of Vascular Lesions Regulation and Remodeling,Fudan University Pudong Medical Center,Shanghai 201399,ChinaDepartment of Rheumatology,Shanghai Pudong Hospital,Human Phenome Institute,Zhangjiang Fudan International Innovation Center,Fudan University,Shanghai 200000,China||Department of Anthropology and Human Genetics,School of Life Sciences,Ministry of Education Key Laboratory of Contemporary Anthropology,Fudan University,Shanghai 200000,China
Iron metabolism;Arthritis;Inflammation;Immunity;Rheumatoid arthritis;Psoriatic arthritis;Gouty arthritis
《中华医学杂志（英文版）》 2024 (014)
1651-1662 / 12
The study was supported by grants from the National Natural Science Foundation of China(Nos.82030003 and 82001726),the CAMS Innovation Fund for Medi-cal Sciences(No.2019-I2M-5-066),and the Shanghai Municipal Science and Technology Major Project(No.2023SHZDZX02).
10.1097/CM9.0000000000003169
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