磷脂酰肌醇3-激酶(PI3K)/蛋白激酶B(Akt)/哺乳动物雷帕霉素靶蛋白(mTOR)信号通路是细胞内重要的代谢、增殖和存活调节途径,对维持细胞的稳态具有关键作用.该信号通路可以通过介导细胞自噬参与多种疾病的发生和发展过程,如肿瘤、神经退行性疾病(ND)和代谢性疾病等.该文就PI3K/Akt/mTOR信号通路在自噬调控中的作用进行综述,以期更好地理解细胞代谢和存活的调节机制,并探究该信号通路在多种疾病中的作用及未来研究方向,为探索新的疾病治疗方法提供参考资料.
Phosphatidylinositol 3-kinase(PI3K)/protein kinase B(Akt)/mammalian target of rapamy-cin(mTOR)signaling pathway is an important regulating pathway for metabolism,proliferation and survival in cells,and plays a pivotal role in maintaining cellular homeostasis.This signaling pathway participates in the occurrence and development process of multiple diseases by mediating the cellular autophagy,such as tumors,neurodegenerative disorders(ND)and metabolic diseases.This paper reviews the role of PI3K/Akt/mTOR signaling pathway in autophagy regulation in order to better understand the regulatory mechanisms of cellular metabolism and survival,moreover investigate the role of this signal pathway in multiple diseases and direc-tion of the future study to provide reference for explore the new disease treatment methods.
李卫胜;王婷婷;何文强
河南中医药大学,郑州 450003河南中医药大学第一附属医院泌尿外科,郑州 450003
基础医学
PI3K/Akt/mTOR信号通路;自噬;疾病;综述
PI3K/Akt/mTOR signaling pathway;autophagy;disease;review
《重庆医学》 2024 (013)
2047-2052 / 6
国家自然科学基金项目(82004311);河南省中医药科学研究专项课题(2022JDZX026).
10.3969/j.issn.1671-8348.2024.13.023
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