Necrotizing enterocolitis(NEC)is a devastating gastrointestinal disease over decades,which,however,remains the leading cause of morbidity and mortality in preterm infants.^([1])Although multiple factors,including gastrointestinal tract bacterial colonization,immaturity,and formula feeding,are reported to be involved in the pathogenesis of NEC,the precise mechanisms are not well understood.Owing to the advances in metagenomic sequencing,ample evidences have illustrated the presence of gut dysbacteriosis in infants with NEC,which is characterized by an elevated abundance of Proteobacteria,reduced abundance of Firmicutes phyla,and an overall decrease in bacterial diversity,providing novel insights into NEC progression.^([1,2])Additionally,the bacterial replication rates,particularly those of Enterobacteriaceae,rapidly increase two days prior to NEC diagnosis.^([2])
Shuqin Zeng;Li Zeng;Panyu Yang;Qu Zheng;Shaopu Wang;
Department of Pediatrics,Key Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University),Ministry of Education,West China Second University Hospital,Sichuan University,Chengdu,Sichuan 610041,ChinaSichuan Jinxin Xinan Women&Children Hospital,Chengdu,Sichuan 610000,China
临床医学
elevated;frontier;treatment;
《Chinese Medical Journal》 2024 (005)
P.562-564 / 3
supported by grants from the National Natural Science Foundation of China(Nos.82100590 and 82241036);the Department of Science and Technology of Sichuan Province(No.2023NSFSC0579).
10.1097/CM9.0000000000002921
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