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黄连-莪术药对配伍规律研究OA北大核心CSTPCD

Study on the Compatibility Rules of Rhizoma Coptidis-Curcumae Rhizoma

中文摘要英文摘要

目的 通过数据挖掘方法分析黄连-莪术的配伍规律.方法 筛选史大卓教授门诊开具处方中含黄连-莪术药味的病例,收集患者性别、年龄、舌脉、中西医诊断和处方用药信息,并进行数据规范化及统计分析.结果 含黄连-莪术药对方剂应用人群的舌质以暗红和紫暗为主,舌体多胖大,苔多腻,脉象以沉弦和沉弦细为主.西医主治疾病主要为冠状动脉粥样硬化性心脏病,中医主治证候主要为心血瘀阻证.黄连:莪术配伍比例一般为0.7、0.5.与黄连-莪术药对共同使用的中药主要包括丹参、赤芍、川芎和黄芪.结论 含黄连-莪术药对的方剂主要用于治疗心血瘀阻证的冠状动脉粥样硬化性心脏病.临床根据血瘀、热毒、痰湿、气虚等病证的轻重变化,配伍比例有所变化,并酌情配伍活血化瘀、清热、补虚和理气中药.

Objective To analyze the compatibility rules of Rhizoma Coptidis-Curcumae Rhizoma with the method of data mining.Methods The patients,prescribed with Rhizoma Coptidis-Curcumae Rhizoma by Professor Shi Da-zhuo in outpatient clinic,were included.The information such as gender,age,tongue and pulse conditions,diagnoses,and used Chinese herbs were collected,normalized and analyzed.Results Rhizoma Coptidis-Curcumae Rhizoma was primarily used in the patients with dark red and purplish tongues,swollen tongues,with greasy coatings,and deep or finely deep pulses.The primary diagnose was coronary atherosclerotic heart disease.The main Chinese medicine syndrome was blood stasis in Xin syndrome.The proportion of Rhizoma Coptidis to Curcumae Rhizoma in the decoction was mainly 0.7 and 0.5.Other commonly used Chinese herbs in combination with Rhizoma Coptidis-Curcumae Rhizoma included Salvia miltiorrhiza Bunge,Radix Paeoniae Rubra,Ligusticum chuanxiong hort,and Radix Astragali.Conclusions Rhizoma Coptidis-Curcumae Rhizoma is mainly used to treat coronary atherosclerotic heart disease with blood stasis syndrome.The proportions of Rhizoma Coptidis-Curcumae Rhizoma may be adjusted based on the severity of blood stasis,heat toxicity,phlegm-dampness,and qi deficiency,and additional herbs for promoting blood circulation,removing blood stasis,clearing heat,tonifying deficiency,and regulating qi may be added accordingly.

袁蛀鱼;曲华;史大卓

北京大学中医药临床医学院(西苑)(北京 100091)||北京大学医学部中西医结合学系(北京 100191)中国中医科学院西苑医院临床药理研究所(北京 100091)||中国中医科学院西苑医院国家中医心血管病临床医学研究中心(北京 100091)中国中医科学院西苑医院国家中医心血管病临床医学研究中心(北京 100091)

药对;配伍;数据挖掘;用药规律;黄连;莪术;中药

drug pair;compatibility;data mining;compatibility rules;Rhizoma Coptidis;Curcumae Rhizoma;Chinese herbal medicine

《中国中西医结合杂志》 2024 (005)

554-557 / 4

国家自然基金青年科学基金项目(No.82104678);中央级公益性科研院所基本科研业务费专项资金资助(No.ZZ15-YQ-006);国家中医药管理局2018年岐黄学者支持项目(No.010120005)

10.7661/j.cjim.20240202.095

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