早期胃癌浸润深度影响因素及预后分析OA

Objective To analyze the risk factors of submucosal invasion and prognostic survival analysis in early gastric cancer(EGC)based on Surveillance,Epidemiology,and End Results(SEER)database.Methods The study selected 591 patients from the SEER database,registered between 2010-2015.The clinicopathological characteristics of EGC mucosal and submucosal invasion were analyzed,and the prognostic factors were analyzed.Results In the 591 patients,the male to female ratio was 10.73.There were 283 cases in the mucosal group and 308 cases in the submucosal group,accounting for 47.9%and 52.1%,respectively.The overall survival rate after 5 years was 70%.Compared with mucosal group,submucosal group had a lower degree of differentiation,more regional lymph node metastasis and more lymph node examination,the degree of differentiation is an independent risk factor for submucosal invasion(P<0.05).Univariate analysis showed that differences were statistically significant in age,gender,race,marital status,primary site,degree of differentiation,tumor size,lymph node metastasis,number of lymph node examination and surgical method(P<0.05).The results of multivariate Cox regression analysis showed that age,gender,marital status,degree of differentiation,tumor size,lymph node metastasis and surgical method were independent risk factors for the prognosis of patients with early gastric cancer.Conclusion The lower the degree of differentiation of early gastric cancer,the higher the risk of submucosal invasion.The influencing factors of prognosis include age,sex,marital status,degree of differentiation,tumor size,lymph node metastasis and mode of operation.