目的 旨在建立浙江省健康成年受试者胃蛋白酶原(pepsinogen,PG)Ⅰ、PGⅡ和PGI/PGⅡ比值的参考区间.方法 收集45 504名健康成年受试者数据,血清PGI和PGⅡ浓度水平通过化学发光微粒子免疫测定法检测.根据CLSI-C28-A3文件确定PG的参考区间.结果 男性血清PGI中位浓度为 132.62μg/L,PGⅡ浓度为 8.10μg/L,PGⅠ/PGⅡ为 15.9.女性分别为107.44μg/L、6.96μg/L和15.0.男性的PGⅠ、PGⅡ浓度和PGⅠ/PGⅡ比值显着高于女性(P<0.001).随着年龄的增长,男性和女性PGⅠ和PGⅡ水平逐渐升高(P均<0.001).男性血清PGI参考区间:19～39岁为59.79～234.97μg/L,40～59岁为63.33～294.62μg/L,≥60 岁为 64.25～333.61μg/L;PGⅡ参考区间:19～39 岁为 3.33～22.60μg/L,40～59 岁为 3.79～33.89μg/L,≥60 岁为 4.15～42.08μg/L;PGⅠ/PGⅡ参考区间:19～39 岁为 7.3～31.4,40～59 岁为 5.8～30.9,≥60 岁为 3.9～30.7.女性PGI参考区间分别为 19～39 岁为 48.79～215.68μg/L、40～59 岁为 52.10～276.01μg/L和≥60 岁为 64.34～317.20μg/L;PGⅡ参考区间分别为 19～39 岁为 2.87～23.93μg/L、40～59 岁为 3.41～33.31μg/L和≥60 岁为 3.88～39.16μg/L;PGⅠ/PGⅡ参考区间分别为 19～39 岁为 6.6～28.1、40～59 岁为 5.2～27.9 和≥60 岁为 3.6～26.2.结论 本研究确定了浙江省不同性别和年龄健康受试者血清PGs缺失的参考范围.
Objective To establish a reference interval for the pepsinogen(PG)Ⅰ,PGⅡ and PGⅠ/PGⅡ in healthy adult subjects in Zhejiang Province.Methods The data of 45 504 healthy adult subjects were collected,and the levels of serum PGⅠ and PG Ⅱ were detected by chemiluminescence microparticle immunoassay.The reference range of PGs were determined according to the CLSI-C28-A3 file.Results The median serum PGⅠ concentration in male was 132.62μg/L,PGⅡ concentration was 8.10μg/L,and PGⅠ/PGⅡ was 15.9.For females,they were 107.44μg/L,6.96μg/L and 15.0,respectively.PGI,PGⅡ concentration and PGⅠ/PGⅡ ratio were significantly higher in males than in females(P<0.001).The levels of PGⅠ and PGⅡ increased with age(P<0.001).Serum PGⅠ reference interval for male:59.79-234.97μg/L for 19-39 years old,63.33-294.62μg/L for 40-59 years old,64.25-333.61μg/L for≥60 years old,PGⅡ reference interval:3.33-22.60μg/L for 19-39 years of age,3.79-33.89μg/L for 40-59 years of age,4.15-42.08μg/L for≥60 years of age,PGⅠ/PGⅡ reference interval:those aged 19-39 years ranged from 7.3 to 31.4,those aged 40-59 years ranged from 5.8 to 30.9,and those aged≥60 years ranged from 3.9 to 30.7.The reference intervals of female PGⅠ were 48.79-215.68μg/L,52.10-276.01μg/L,and 64.34-317.20μg/L,respectively.The reference intervals of female PgⅡwere:2.87-23.93μg/L,3.41-33.31μg/L and 3.88-39.16μg/L,respectively.The reference intervals of of female PGⅠ/PGⅡ are 6.6-28.1,5.2-27.9 and 3.6-26.2.Conclusion This study determined the reference range of serum PGs deficiency in healthy subjects of different sex and age in Zhejiang Province.
徐秀湖;阳愿望;曹芳芳;解鸿翔;周斐斐
湖州市中医院检验科,浙江湖州 3130000杭州艾迪康医学检验中心有限公司,浙江杭州 310030山东第一医科大学第一附属医院(山东省千佛山医院)检验医学科,山东济南 250014||浙江省人民医院(杭州医学院附属人民医院)检验医学中心,浙江杭州 310014浙江省人民医院(杭州医学院附属人民医院)检验医学中心,浙江杭州 310014
临床医学
胃蛋白酶原;参考区间;化学发光微粒子免疫测定法;健康人群
Pepsinogen;Reference intervals;Chemiluminescent microparticle immunoassay;Healthy population
《中国现代医生》 2024 (014)
1-5 / 5
山东省自然科学基金项目(ZR2020MH116);浙江省中医药科技计划项目(2023ZL009);浙江省高校基本科研经费专项(KYYB202216);浙江省教育厅一般科研项目(Y202146133);浙江省医药卫生科技计划项目(2021KY017,2022KY027)
10.3969/j.issn.1673-9701.2024.14.001
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