糖尿病肾病(DKD)是糖尿病最重要的并发症之一.近年来,国内外研究发现,哺乳动物西罗莫司靶蛋白(mTOR)相关信号通路是参与自噬调节的一个经典通路,可通过靶向自噬途径达到治疗DKD的效果,在防治DKD中发挥着至关重要的作用.本文将主要从中医药干预mTOR相关信号通路靶向自噬防治DKD的作用机制做一综述,以期为临床防治DKD提供新的参考及依据.
Diabetic kidney disease(DKD)is one of the most important complications of diabetes.In recent years,domestic and foreign studies have found that mammalian target protein of rapamycin(mTOR)related signaling pathway is a classic pathway involved in the regulation of autophagy,which can achieve the therapeutic effect of DKD by targeting the autophagy pathway,and plays a crucial role in the prevention and treatment of DKD.In this paper,we reviewed the mechanism of mTOR-related signaling pathway targeted autophagy in the prevention and treatment of DKD,in order to provide a new reference and basis for clinical prevention and treatment of DKD.
杨世睿;周婷婷;马超超;杨鹏斐;牛凡琪;杜雪洋;闫丰喆;王思农
甘肃中医药大学中医临床学院,甘肃兰州 730000
药学
磷酸肌醇-3-激酶/蛋白激酶B/哺乳动物西罗莫司靶蛋白信号通路;腺苷酸活化蛋白激酶/哺乳动物西罗莫司靶蛋白信号通路;自噬;糖尿病肾病
phosphoinositol 3 kinase/protein kinase B/mammalian rapamycin target pathway;adenosine monophosphate-activated protein kinase/mammalian target of rapamycin signaling pathway;autophagy;diabetic kidney
《中国临床药理学杂志》 2024 (011)
1675-1678 / 4
甘肃省教育厅产业支撑计划基金资助项目(2021CYZC-03)
10.13699/j.cnki.1001-6821.2024.11.029
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