mRNA疫苗具有高效性、安全性、快速发展的潜力、成本效益高等优势,已成为癌症和传染性疾病的强大治疗平台.通过对mRNA疫苗结构修饰和递送方式改进,有效改善了 mRNA疫苗不稳定性和体内传递效率低等缺点.根据目前已批准的mRNA疫苗和mRNA疫苗的临床试验,本文综述了 mRNA疫苗的分类、结构修饰、作用机制以及在癌症和传染性疾病方面的应用等,并且讨论了mRNA疫苗目前面临的挑战和未来的发展前景.
With the advantages of high efficiency,safety,potential for rapid development,and cost-effectiveness,mRNA vaccines have become a powerful therapeutic platform for cancer and infectious diseases.The shortcomings of mRNA vaccines,such as instability and low in vivo delivery efficiency,have been effectively improved by structural modification of mRNA vaccines and delivery improvement.Based on the currently approved mRNA vaccines and clinical trials of mRNA vaccines,this paper reviews the classification,structural modification,mechanism of action,and applications of mRNA vaccines in cancer and infectious diseases,and discusses the current challenges and future development prospects of mRNA vaccines.
李灿;刘爽;张雪
佳木斯大学基础医学院微生物-免疫调节网络与相关疾病重点实验室,黑龙江佳木斯 154000
药学
mRNA疫苗;癌症;传染性疾病;递送系统
mRNA vaccines;cancer;infectious diseases;delivery sys-tems
《中国临床药理学杂志》 2024 (011)
1665-1669 / 5
佳木斯大学博士专项科研基金资助项目(JMSUZ2019-02)
10.13699/j.cnki.1001-6821.2024.11.027
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