Stress is a common risk factor for emotional and cognitive dysfunction during mammalian growth and development.The hippocampal neurogenesis,which regulates the stress response,is highly susceptible to stress stimu-li.This review focuses on the pathomechanism underlying how stress stimuli affect hippocampal neurogenesis and explores the impact of aberrant 5-hydroxytryptamine(5-HT)system,including 5-HT,5-HT receptors and 5-HT neurons,on stress-induced impairment of hippocampal neurogenesis.By summarizing existing research,we aim to provide new ideas for the treatment of post-traumatic stress disorder and depression.
朱乐;廖疏影;曾燕;梅宇飞
武汉科技大学脑科学先进技术研究院,湖北 武汉 430065职业危害识别与控制湖北省重点实验室,湖北 武汉 430065武汉科技大学脑科学先进技术研究院,湖北 武汉 430065||职业危害识别与控制湖北省重点实验室,湖北 武汉 430065
临床医学
5-羟色胺;应激;神经发生;海马
5-hydroxytryptamine;stress;neurogenesis;hippocampus
《中国病理生理杂志》 2024 (005)
944-949 / 6
国家自然科学基金资助项目(No.82201351);职业危害识别与控制湖北省重点实验室开放基金项目(No.0HIC2021Z07)
10.3969/j.issn.1000-4718.2024.05.021
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