N6-methyladenosine(m6A)denotes the addition of a methyl group to the sixth nitrogen atom of ade-nosine,a common occurrence in eukaryotic RNA.The m6A modifications govern RNA splicing,translocation,stability,and translation into proteins.The RNA methyltransferases,like methyltransferase-like protein 3(METTL3),METTL14,and Wilms'tumor 1-associated protein(WTAP),are responsible for these modifications,while the removal process in-volves demethylases,specifically fat mass and obesity-associated protein(FTO)and ALKB homolog 5(ALKBH5).Recog-nition of these modifications is facilitated by m6A-binding proteins,such as YTH family proteins and insulin-like growth factor 2 mRNA-binding proteins(IGF2BPs).The m6A modification regulators are involved in the onset and progression of non-small-cell lung cancer through multiple mechanisms.This review concentrates on the biological functions and molecu-lar mechanisms of m6A modification-related regulatory factors in the malignant progression of non-small-cell lung cancer.
张乃祥;林江霞;彭金芝;曾俊伟;陈远寿;金寰
遵义医科大学生理学教研室,贵州 遵义 563000
临床医学
非小细胞肺癌;m6A修饰;甲基转移酶;去甲基化酶
non-small-cell lung cancer;m6A modification;methyltransferases;demethylases
《中国病理生理杂志》 2024 (005)
917-923 / 7
国家自然科学基金资助项目(No.81960510);遵义医科大学2018年度学术新苗培养及创新探索专项项目(黔科合平台人才[2018]5772-009号)
10.3969/j.issn.1000-4718.2024.00.008
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