目的:探讨 PRARGC1A 基因 rs8192678 位点基因多态性、孕前体重指数(BMI)及两者的交互作用与妊娠期糖尿病(GDM)遗传易感性的关系.方法:收集 2021年3 月至2021 年9 月在甘肃省妇幼保健院住院待产的292 例GDM患者(GDM)和292 例非GDM患者(对照组).检测外周血中rs8192678 基因多态性和孕前BMI.分析基因与孕前BMI的交互作用与GDM遗传易感性的关系.结果:孕前超重/肥胖(OR=2.36,95%CI为1.531～3.643)与GDM易感相关;携带CT+TT基因型、TT基因型增加GDM患病风险.此外,显性模型(CT+TT)与孕前超重/肥胖存在联合作用;隐性模型TT基因型与孕前超重/肥胖存在联合作用,均增加GDM发病风险.结论:孕前超重/肥胖是GDM的危险因素;PRARGC1A基因rs8192678 位点可能是GDM的易感基因,且与孕前超重/肥胖存在联合作用.
Objective:To investigate loci polymorphisms of the PRARGC1A gene rs8192678 and the association of gene-pre-pregancy body mass index(BMI)interaction with the susceptibility to gestational diabetes mellitus(GDM).Methods:A total of 292 GDM patients admitted for delivery in Gansu Provincial Maternal and Child Health Care Hospital from March 2021 to September 2021 were included as the case group,292 non-GDM pregnant women were 1∶1 matched with age in control group.rs8192678 gene polymorphism in peripheral blood and pre-pregancy BMI were detected.The association of gene-pre-pregancy BMI interaction with the susceptibility to GDM was analyzed.Results:Pre-pregnancy overweight/obesity(OR=2.36,95%CI:1.531～3.643)was associated with susceptibility to GDM.Carrying the CT+TT geno-type and TT genotype increased the risk of GDM.In addition,the dominant model(CT+TT)and the recessive model(TT)had combined effects with pre-pregnancy overweight/obesity,both increasing the risk of developing GDM.Conclusion:Pre-pregnancy overweight/obesity was a risk factor for GDM.The PRARGC1A gene rs8192678 locus might be a susceptible gene for GDM,and it interacted with pre-pregnancy overweight/obesity.
张喜荣;史绪生;李斐;郭志茹;易彬;王燕侠
甘肃中医药大学公共卫生学院,兰州 730101||聊城市人民医院重症医学科,聊城 252000聊城市人民医院重症医学科,聊城 252000甘肃中医药大学公共卫生学院,兰州 730101甘肃省妇幼保健院科研中心,兰州 730050
临床医学
妊娠期糖尿病;叉生分析;相乘交互作用;相加交互作用;Logistic回归
Gestational diabetes mellitus;Crossover analysis;Multiplicative interac-tion;Additive interaction;Logistic regression
《现代妇产科进展》 2024 (006)
445-450 / 6
甘肃省自然科学基金项目(No:20JR10RA427);国家儿童健康与疾病临床医学研究中心项目(No:NCRCCHD-2020-GP-15)
10.13283/j.cnki.xdfckjz.2024.06.004
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