伴有口腔扁平湿疣及指甲损害的少见神经梅毒1例OA

A rare case of neurosyphilis with oral condyloma lata and fingernail damage is repor-ted.A 49-year-old male presented with a two-month history of copper-red macules on the palms of both hands and verrucous plaques on the tongue tip for 1 month,and dark shadows on the left eye for 1 week.Dermatological examination revealed uneven and partially thickened nail surfaces of the left thumb and right index finger.The palms were scattered with copper-red macules in the size of mung beans,surrounded by collar-like desquamation.Flat-topped verrucous plaques could be seen on the mucosa of the tongue tip.Hearing was slightly less in the left ear than in the right ear.Corrected visual acuity was 1.0 in the right eye and 0.8 in the left eye.Laboratory tests showed positive for both serum Treponema pallidum particle agglutination(TPPA)(＞1∶1 280)and To-lulized red unheated serum test(TRUST)(1∶64).Moreover,the cerebrospinal fluid(CSF)was positive for TRUST(1∶1),TPPA(1∶640)and venereal disease research laboratory(VDRL)(1∶2).The presence of Treponema Pallidum(T.Pallium)in oral verrucous plaque was confirmed by metagenomics next-generation sequencing(mNGS)technology.The diagnosis was neurosyphilis,secondary syphilis(oral flat condyloma).After 2 weeks of treatment with aqua pen-icillin at a dose of 4 million U q4h,almost all clinical manifestations were improved.Serum TRUST titer was decreased to 1∶8 after 3 months.The follow-up is still ongoing.