典型的皮肤纤维化疾病包括增生性瘢痕、瘢痕疙瘩、硬皮病等.该类疾病以肌成纤维细胞过度激活和细胞外基质沉积为特征,可导致永久性瘢痕和器官功能损伤,严重影响患者身心健康.肌成纤维细胞在皮肤纤维化疾病中起到了核心作用.目前研究表明,成纤维细胞、内皮细胞、周细胞、巨噬细胞等细胞可在经历促纤维化的介质等多因素的诱导、皮肤纤维化相关信号通路的激活、形态学和生化特征的改变、α-平滑肌肌动蛋白(α-SMA)等肌成纤维细胞标记物的表达等过程后,转化为肌成纤维细胞.靶向这些细胞转化的过程有望成为调控皮肤纤维化疾病进展的新治疗策略.本文重点围绕皮肤纤维化疾病中肌成纤维细胞来源的相关进展作一综述.
Typical skin fibrotic diseases include hypertrophic scar,keloid and scleroderma.These diseases characterized by excessive activation of myofibroblast,and abnormal deposition of extracellular matrix can lead to permanent scarring and organ dysfunction,and seriously affect the physical and mental health of patients.Myofibroblasts play a central role in skin fibrotic diseases.Current studies have shown that fibroblasts,endothelial cells,pericytes,macrophages and other cells can be transformed into myofibroblasts after induction by multiple factors such as pro-fibrotic mediators,activation of signaling pathways related to skin fibrosis,changes in morphological and biochemical characteristics,and expression of myofibroblast markers,including α-smooth muscle actin(α-SMA).Targeting these cell transformation processes is expected to be a new therapeutic strategy for regulating the progression of skin fibrotic disease.Therefore,this review will focus on the progress of the origins of the myofibroblasts in skin fibrotic diseases.
朱显忠;麦佩君;韦阳海;魏茂云;邱创烨;张沛然;齐庆
广州医科大学附属第二医院,广东 广州 510260||广州医科大学附属第二医院变态反应(过敏)中心,广东 广州 510260广州医科大学附属第二医院,广东 广州 510260
肌成纤维细胞;皮肤纤维化;肌成纤维细胞来源
myofibroblast;skin fibrosis;origins of myofibroblast
《皮肤性病诊疗学杂志》 2024 (005)
340-346 / 7
广州市科技计划项目(202201020091);广东省大学生创新创业项目(S202310570090);广州医科大学学生创新能力提升计划项目(02-408-2203-2122);广州医科大学第二临床学院大学生科技创新项目(S2023A013)
10.3969/j.issn.1674-8468.2024.05.008
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