系统性硬化症合并肢端溃疡的临床特征OA

Objective To explore the characteristics of systemic sclerosis with acro-ulceration(SSc-DUs)and its association with organ involvement and autoantibodies in order to improve the understanding of the disease.Methods The clinical data of 70 patients with SSc-DUs were ana-lyzed retrospectively,and the sites of ulcer and organ involvement were also analyzed.The clinical data of 155 patients with systemic sclerosis without acroulcers(SSc-No-DUs)were used as con-trols to assess the association between SSc-DUs and organ involvement and autoantibodies.Results The most common sites of ulcers were the fingertips(51.43％),interphalangeal joints(22.86％)and toes(15.71％),while the involvements of the heel,elbow and ankle joints were relatively rare.The rates of heart failure(31.42％)and esophageal involvement(65.71％)in SSc-DUs group were higher than those in SSc-No-DUs group(both P＜0.05).The positive rates of anti-SCL-70 antibody(80.00％),anti-SSA antibody(38.57％)and anti-Ro-52 antibody(22.86％)in SSc-DUs group were higher than those in SSc-No-DUs group(all P＜0.05).There were no significant differences in the incidence of the lung,kidney and thyroid diseases,positive titer of anti-nuclear antibody,typing of anti-nuclear antibody,immunoglobulin and complement levels between the two groups(all P＞0.05).Conclusions The ulcers in patients with SSc-DUs are more common in the fingertips and interphalangeal joints.SSc-DUs patients are more likely to have esophageal involvement and a higher incidence of heart failure.Anti-Scl-70 antibody(+),anti-SSA antibody(+),and anti-Ro-52 antibody(+)may be danger signs of the development of ulcers.