传统中药延缓衰老历史悠久,以补虚药和活血化瘀药为主,如人参、黄芪、桂附地黄丸、四君子汤、参芪白术散等,主要是通过调控Wnt、Notch、MAPK、EGFR、mTOR等肠道干细胞衰老相关信号通路,发挥清除自由基、提高抗氧化酶活性及调节免疫功能等作用,从而延缓肠道衰老.然而,肠道衰老致组织结构及功能发生改变的具体作用机制尚未明确,需进一步加强研究,同时,探讨如何将天然药物安全有效地应用于临床以延缓衰老亦可作为今后的研究方向.
In traditional Chinese medicine,there is a long history of delaying aging,mainly with deficiency tonifying drugs and blood-activating drugs to remove blood stasis,such as Renshen(Ginseng Radix et Rhizoma),Huangqi(Astragal Radix),Guifu Dihuang Pill,Sijunzi Decoction,Shenqi Baizhu Powder,etc.mainly through the regulation of intestinal stem cell aging related signaling pathways such as Wnt,Notch,MAPK,EGFR,mTOR.It can remove free radicals,improve the activity of antioxidant enzyme,and regulate immune func-tion,so as to delay intestinal aging.However,the specific mechanism of the changes in tissue structure and function caused by intestinal aging is not yet clear,and further studies are needed.Meanwhile,the future research direction is to explore how to apply natural drug safely and effectively in clinical treatment to delay aging.
郭璐璐;李寒冰;李根林;吴宿慧
河南中医药大学,河南 郑州 450046
中医学
衰老;肠道干细胞;信号通路;中药;人参;黄芪;桂附地黄丸;四君子汤
aging;intestinal stem cell;signaling pathway;Chinese medicine;Renshen(Ginseng Radix et Rhizoma);Huangqi(Astragal Radix);Guifu Dihuang Pill;Sijunzi Decoction
《中医学报》 2024 (006)
1224-1230 / 7
河南省中医药科学研究专项项目(20-21ZY1038)
10.16368/j.issn.1674-8999.2024.06.205
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