Diabetic cardiomyopathy is defined as abnormal structure and function of the heart in the setting of diabetes,which could eventually develop heart failure and leads to the death of the patients.Although blood glucose control and medications to heart failure show beneficial effects on this disease,there is currently no specific treatment for diabetic cardiomyopathy.Over the past few decades,the pathophysiology of diabetic cardiomyopathy has been extensively studied,and an increasing number of studies pinpoint that impaired mitochondrial energy metabolism is a key mediator as well as a therapeutic target.In this review,we summarize the latest research in the field of diabetic cardiomyopathy,focusing on mitochondrial damage and adaptation,altered energy substrates,and potential therapeutic targets.A better understanding of the mitochondrial energy metabolism in diabetic cardiomyopathy may help to gain more mechanistic insights and generate more precise mitochondria-oriented therapies to treat this disease.
Wanlin Ye;Kun Han;Maodi Xie;Sheyu Li;Guo Chen;Yanyan Wang;Tao Li
Department of Anesthesiology,Laboratory of Mitochondria and Metabolism,National Clinical Research Center for Geriatrics,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,ChinaDepartment of Anesthesiology,West China Second University Hospital,Sichuan University,Chengdu,Sichuan 610041,China||Key Laboratory of Birth Defects and Related Diseases of Women and Children,Sichuan University,Ministry of Education,Chengdu,Sichuan 610041,ChinaDepartment of Endocrinology and Metabolism,Division of Guideline and Rapid Recommendation,Cochrane China Center,MAGIC China Center,Chinese Evidence-Based Medicine Center,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,ChinaNursing Key Laboratory of Sichuan Province,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China
Mitochondria;Mitochondrial energy metabolism;Diabetic cardiomyopathies;Physiology;Physiological adaption;Pathogenesis;Therapeutics
《中华医学杂志（英文版）》 2024 (008)
936-948 / 13
This study was supported in part by grants from Yunnan Provincial Cardiovascular Disease Clinical Medical Center Project(Nos.FZX2019-06-01,2022YFKY078),the Key Research and Development Program of Sichuan Province(Nos.2022YFS0132,2022YFS0198 and 2023YFS0295),and the National Natural Science Foundation of China(Nos.81970715 and 82370260).
10.1097/CM9.0000000000003075
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