脂质代谢异常在肿瘤的发生演进、药物治疗抵抗、转移过程中起到重要作用.脂肪酸代谢是脂质代谢的主要组成部分,其代谢过程中的一些关键酶成为研究热点.笔者就四种脂肪酸代谢相关酶(脂肪酸合成酶、固醇调节元件结合蛋白1、肉碱脂酰转移酶1和CD36)在胃癌发生发展中的作用以及其对胃癌的诊断、治疗及预后评估的潜在意义作一综述.
Abnormal lipid metabolism plays an important role in the initiation and progression of tumors,as well as in their resistance to drug therapy and metastasis.Fatty acid metabolism is the main component of lipid metabolism,and some key enzymes in this metabolic process have become the focus of research.Here,the authors address four fatty acid metabolism-related enzymes(fatty acid synthetase,sterol regulatory element-binding protein 1,carnitine palmitoyltransferase 1,and CD36)in terms of their roles in the occurrence and development of gastric cancer as well as their potential significance in the diagnosis,treatment and prognosis evaluation of gastric cancer
金惠敏;周韵斓;汪逸舟;陈雨洁;李冬冬;陈磊
上海交通大学医学院附属新华医院普通外科,上海 200092上海交通大学医学院附属新华医院检验科,上海 200092
临床医学
胃肿瘤;脂类代谢;脂肪酸合成酶;综述
Stomach Neoplasms;Lipid Metabolism;Fatty Acid Synthases;Review
《中国普通外科杂志》 2024 (004)
642-648 / 7
上海市卫生健康委员会科研基金资助项目(202340054).
10.7659/j.issn.1005-6947.2024.04.014
评论