目的 本研究旨在探究复方口服硫酸盐溶液用于结肠息肉术前清肠的临床疗效.方法 将接受结肠息肉切除术的患者按照队列法分为对照组和试验组.对照组患者给予复方聚乙二醇电解质散,在结肠镜检查前4～6 h开始服用,2 h内服完4 L溶液;试验组患者给予复方口服硫酸盐溶液,术前1天的傍晚服用复方口服硫酸盐溶液1.5 L,手术当天重复前1天傍晚的服药方法.比较2组患者的肠道清洁程度(波士顿肠道准备评分,BBPS),肠道准备依从性,药物耐受性,患者满意度以及药物不良反应发生率.结果 对照组和试验组各40例,对照组和试验组BBPS总评分分别为(6.68±1.19)和(7.43±1.23)分,在统计学上差异有统计学意义(P＜0.01).对照组和试验组患者服药依从性分别为70.00％(28例/40例)和95.00％(38例/40例),运动依从性分别为67.50％(27例/40例)和97.50％(39例/40例),药物耐受性分别为67.50％(27例/40例)和90.00％(36例/40例),患者对肠道准备的满意度评分分别为(1.89±0.75)和(2.42±0.43)分,对照组上述指标与试验组比较,在统计学上差异均有统计学意义(P＜0.05,P＜0.01,P＜0.001).对照组和试验组主要药物不良反应有恶心和呕吐,对照组和试验组药物不良反应发生率分别是10.00％(4例/40例)和5.00％(2例/40例),2组患者药物不良反应发生率比较,在统计学上差异无统计学意义(P＞0.05).结论 服用复方口服硫酸盐溶液进行肠道准备,其肠道清洁效果优于复方聚乙二醇电解质散,患者的依从性以及对药物的耐受性更高,并且可以有效提高患者的满意度.
Objective To investigate the clinical efficacy of a compound oral sulfate solution for preoperative bowel cleansing in colonic polyp patients.Methods Patients who underwent colonoscopic polypectomy were divided into control group and treatment group according to cohort method methods.Patients in the control group were given compound polyethylene glycol electrolyte powder.They started taking it 4-6 hours before colonoscopy and completed the 4 liters of solution within 2 hours.Patients in the treatment group were given a compound oral sulfate solution.They took 1.5 liters of the solution the evening before surgery and repeated the same dosage on the day of the operation.Intestinal cleanliness was assessed using the Boston bowel preparation scale(BBPS),bowel preparation compliance,drug tolerance,patient satisfaction,and incidence of adverse drug reactions were compared between the two groups.Results Control group and treatment group each consisted of 40 cases.The total BBPS scores for the control group and treatment group were(6.68±1.19)and(7.43±1.23)points,respectively.This difference was statistically significant(P＜0.01).Medication compliance rates in the control group and treatment group were 70.00％(28 cases/40 cases)and 95.00％(38 cases/40 cases),respectively;movement compliance rates were 67.50％(27 cases/40 cases)and 97.50％(39 cases/40 cases)in the two groups,while medication tolerance rates were 67.50％(27 cases/40 cases)and 90.00％(36 cases/40 cases);patient satisfaction with bowel preparation were(1.89±0.75)and(2.42±0.43)points for the control and treatment groups,respectively;statistically significant differences were found between the control and treatment groups in all the above indicators(P＜0.05,P＜0.01,P＜0.001).The main adverse drug reactions in the control and treatment groups were nausea and vomiting,with occurrence rates of 10.00％(4 cases/40 cases)and 5.00％(2 cases/40 cases),respectively.The comparison of adverse drug reactions occurrence rate between the two groups showed no statistically significant difference(P＞0.05).Conclusion Taking compound oral sulfate solution for intestinal preparation,the intestinal cleaning effect is better than that of compound polyethylene glycol electrolyte powder,and the patient's compliance and drug tolerance are higher,and the patient's satisfaction can be effectively improved.
刘静;叶献词;徐正富;汪全红
铜陵市人民医院消化内科,安徽铜陵 244000铜陵市人民医院内镜中心,安徽铜陵 244000
药学
复方聚乙二醇电解质散;复方口服硫酸盐溶液;结肠息肉;肠道准备;临床疗效
compound polyethylene glycol electrolyte powder;oral sulfate solution;colonic polyps;intestinal preparation;clinical effectiveness
《中国临床药理学杂志》 2024 (008)
1136-1139 / 4
10.13699/j.cnki.1001-6821.2024.08.010
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