目的 探索儿童非重型再生障碍性贫血(NSAA)的中医证候分布规律,为临床辨证治疗提供参考.方法 收集2019年1月—2021年12月期间确诊的NSAA患儿,制定证素调查问卷并进行临床信息采集,采用因子分析、聚类分析的方法,探索NSAA患儿中医证候分布规律.结果 共纳入NSAA患儿368例,收集频率＞15％的中医证候共54个.因子分析获得公因子16个,NSAA患儿主要病位证素分布在脾、肾、肝,主要病性证素为气虚、血虚、阴虚、阳虚、痰湿.对 16个公因子进一步进行聚类分析,最终归纳为5个中医证型,分别为脾气亏虚证、气血两虚证、肾阴虚证、肾阳虚证、肾阴阳两虚证.结论 儿童NSAA病位主要在脾、肾、肝,中医主要证型为脾气亏虚证、气血两虚证、肾阴虚证、肾阳虚证和肾阴阳两虚证.
Objective To explore the distribution of Chinese medicine(CM)syndromes of children with non-severe aplastic anemia(NSAA),and to provide reference for CM clinical sydrome differentiation and classification of NSAA.Methods Children diagnosed with NSAA between January 2019 and December 2021 were recruited in this study.A questionnaire was developed to investigate the elements of syndrome and clinical information was collected accordingly.Factor analysis and cluster analysis were used to explore the distribution of CM syndromes among children with NSAA.Results A total of 368 patients were recruited in this study,and 54 CM syndromes were collected with a frequency of＞15％.Factor analysis resulted in the identification of 16 common factors.In terms of disease location of NSAA,the main syndrome elements were Pi,Shen and Gan,while the disease nature syndrome elements were mainly qi deficiency,blood deficiency,yin deficiency,yang deficiency and phlegm-dampness.Further cluster analysis of the 16 common factors revealed that CM syndromes could be summarized into five categories:deficiency of Pi-qi,qi and blood deficiency,Shen-yin deficiency,Shen-yang deficiency,and Shen yin-yang deficiency.Conclusions The main disease location of children with NSAA was in the Pi,Shen and Gan.The CM syndromes mainly include five types which were deficiency of Pi-qi,qi and blood deficiency,Shen-yin deficiency,Shen-yang deficiency,and Shen yin-yang deficiency
黄莉荣;薛征;陈静;尤焱南;崔雯;王雅娟
上海中医药大学附属市中医医院儿科(上海 200071)上海交通大学医学院附属上海儿童医学中心血液肿瘤科(上海 200127)
儿童非重型再生障碍性贫血;证素;中医证候;因子分析;聚类分析
children with non-severeaplastic anemia;syndrome element;CM syndrome;factor analysis;cluster analysis
《中国中西医结合杂志》 2024 (004)
426-431 / 6
国家自然科学基金资助项目(No.82274576);儿科中西医协同诊疗网络建设项目[No.ZY(2021-2023)-0206-04];海派中医徐氏儿科学术传承及创新团队建设项目(No.2021LPTD-006)
10.7661/j.cjim.20240308.041
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