目的 探讨中药复幼合剂对乳房早发育患儿的减重效果.方法 回顾性收集规律随访时间超过6个月的乳房早发育的女童202例,根据有无应用复幼合剂分治疗组114例(用药超过6个月),对照组88例(未用药).观察两组患儿治疗前后体格[包括体重、体重标准差评分(SDS)、身高、体重指数(BMI)、BMI SDS]及性发育指标[包括黄体生成素(LH)、卵泡刺激素(FSH)、雌二醇(E2)、子宫长径及卵巢容积]情况.结果 与本组治疗前比较,治疗组治疗3、6个月时,患儿体重SDS、BMI SDS均降低(P＜0.05);用药3～6个月期间治疗组患儿体重、BMI控制程度,较用药前3个月减缓(P＜0.05);治疗3个月时,对照组患儿LH、FSH、子宫长径逐渐升高(P＜0.05);治疗6个月时,治疗组患儿FSH、E2、卵巢容积降低(P＜0.05),对照组患儿LH、FSH、E2、子宫长径、卵巢容积逐渐升高(P＜0.05).与对照组同期比较,治疗组患儿体重、体重SDS、BMI、BMI SDS增长程度均降低(P＜0.05);治疗3个月时,治疗组患儿子宫长径、卵巢容积较低(P＜0.05),治疗6个月时,治疗组患儿FSH、E2、子宫长径、卵巢容积较低(P＜0.05).治疗组6个月期间,仅2例患儿出现轻微腹部不适,所有患儿均无皮疹、纳差、腹泻等表现,肝肾功能检查未见异常.结论 治疗性早熟的药物复幼合剂,有减重效果,尤其是在用药前3个月更明显.
Objective To investigate the weight loss effect of Chinese medicine Fuyou Formula(FYF)in children with premature breast development.Methods A total of 202 girls of premature breast development with a follow-up time of more than 6 months were collected retrospectively.The patients were divided into a treatment group(received FYF)and a control group(did not receive medication).Totally 114 girls in the treatment group(used for more than 6 months)and 88 in the control group(not used any drug).The physical condition[including body weight,weight standard deviation score(SDS),height,body mass index(BMI)and BMI SDS]and pubertal development indicators[including luteinizing hormone(LH),follicle stimulating hormone(FSH),estradiol(E2),uterine diameter,and ovarian volume)]were observed in the two groups before and after treatment.Results Compared with baseline in the treatment group,the body weight SDS and BMI SDS of the patients decreased at 3 and 6 months of treatment(P＜0.05).During the 3-6 month period of medication,the control of weight and BMI in the treatment group slowed down compared to the first 3 months of medication(P＜0.05);LH,FSH,and uterine length of the treatment group gradually increased after 3 months of treatment(P＜0.05);at 6 months of treatment,FSH,E2,and ovarian volume of the treatment group decreased(P＜0.05),while LH,FSH,E2,uterine length,and ovarian volume of the control group gradually increased(P＜0.05).Compared with the control group during the same period,the growth degrees of body weight,body weight SDS,BMI,and BMI SDS in the treatment group were all reduced(P＜0.05),the uterine length and ovarian volume of the treatment group at 3 months of treatment were lower(P＜0.05),and FSH,E2,uterine length,and ovarian volume of the treatment group at 6 months of treatment were lower(P＜0.05).During the 6-month period of treatment,only 2 cases of mild abdominal discomfort occurred,and all the patients had no rash,poor appetite,diarrhea,etc.Liver and kidney function tests showed no abnormalities.Conclusion FYF for the treatment of precocious puberty has weight loss effect,especially in the first 3 months of medication.
赵曼曼;曹冰燕;刘美娟;王雨思;巩纯秀
国家儿童医学中心首都医科大学附属北京儿童医院内分泌与遗传代谢科(北京 100045)||首都医科大学附属北京潞河医院儿科(北京 101100)国家儿童医学中心首都医科大学附属北京儿童医院内分泌与遗传代谢科(北京 100045)
复幼合剂;乳房早发育;减重;中药复方;中西医结合;队列研究
Fuyou Formula;premature breast development;weight loss;Chinese herbal compound;integrative medicine;cohort study
《中国中西医结合杂志》 2024 (004)
419-425 / 7
10.7661/j.cjim.20240308.043
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