目的 探讨肝素结合蛋白(heparin-binding protein,HBP)与脓毒症患者血管通透性的相关性.方法 回顾性选取2019 年 11 月至 2022 年 11 月浙江大学医学院附属金华医院收治的 400 例感染患者,根据是否诊断为脓毒症将其分为脓毒症组(n=190)和非脓毒症组(n=210).比较两组患者的HBP、血细胞比容(hematocrit,HCT)与血清白蛋白(albumin,ALB)差值(HCT-ALB)及液体超负荷百分比.采用Pearson法分析HBP与HCT-ALB、液体超负荷百分比的相关性.结果 脓毒症组患者的HBP、HCT-ALB及液体超负荷百分比均显著高于非脓毒症组(P<0.05);Pearson相关性分析结果显示,入院后 24h血清HBP水平与HCT-ALB及液体超负荷百分比均呈正相关(P<0.05).结论 脓毒症患者的血管通透性增加,可能与细菌毒素刺激中性粒细胞释放高水平HBP有关.
Objective To investigate the correlation between heparin-binding protein(HBP)and vascular permeability in patients with sepsis.Methods Four hundred infected patients admitted to Affiliated Jinhua Hospital Zhejiang University School of Medicine from November 2019 to November 2022 were retrospectively selected and divided into sepsis group(n=190)and non-sepsis group(n=210)according to whether they were diagnosed with sepsis or not.HBP,the difference between hematocrit(HCT)and serum albumin(ALB)(HCT-ALB)and percentage of fluid overload were compared between two groups.Pearson method was used to analyze the correlation between HBP,HCT-ALB and percentage of liquid overload.Results HBP,HCT-ALB and percentages of fluid overload in sepsis group were significantly higher than those in non-sepsis group(P<0.05).Pearson correlation analysis showed that serum HBP level was positively correlated with HCT-ALB and percentage of fluid overload 24h after admission(P<0.05).Conclusion Increased vascular permeability in patients with sepsis may be related to the high level of HBP released by neutrophils stimulated by bacterial toxins.
朱秀琪
浙江大学医学院附属金华医院重症医学科,浙江金华 321000
临床医学
脓毒症;肝素结合蛋白;血管通透性;液体超负荷
Sepsis;Heparin-binding protein;Vascular permeability;Fluid overload
《中国现代医生》 2024 (010)
32-35 / 4
浙江省金华市科技计划项目(2021-4-037)
10.3969/j.issn.1673-9701.2024.10.008
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