语言流畅孤独症谱系障碍儿童核心症状与智商关系研究OA北大核心CSTPCD

Objective To explore the relationship between core symptoms and Intelligence Quotient(IQ)of 6～18 year old children with autism spectrum disorders(ASD)who are fluent in speech,and provide reference for the formulation of individualized intervention goals for them.Methods The 6～18-year old verbally fluent children with ASD who met the diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders Fifth Edition(DSM-V)were selected as the observation group(n=183).At the same time,normal children(n=91)who underwent physical examination were selected as the control group.The core symptoms of ASD children were quantitatively scored using the Autism Diagnostic Observation Schedule(ADOS,module 3).Wechsler Intelligence Scale for Children-Fourth Edition(Chinese version)(WISC-Ⅳ)was used to measure the children's IQ.Pearson correlation analysis was used to explore the relationship between core symptoms and IQ.Results The average total IQ,verbal comprehension,perceptual reasoning,working memory and processing speed index of 6～18-year old verbally fluent children with ASD were lower than those of normal children,and the differences were statistically significant(all P＜0.05).About 61.7％of the children with ASD had an average IQ,while 27.9％were below the average.There was no gender difference between ASD and normal children in total IQ,language comprehension,working memory or processing speed(all P＞0.05).In terms of perceptual reasoning,ASD boys had higher scores than girls,and the difference was statistically significant(P＜0.05),but there was no difference in normal children.In terms of ADOS communication scores,social interaction scores,communication+social interaction scores,and stereotyped scores,there was no significant difference either between ASD boys and girls,or among different age groups of ASD children(all P＞0.05).ADOS communication score,social interaction score and total communication+social interaction score were all negatively correlated with total IQ(r=-0.43,P＜0.01;r=-0.31,P＜0.01;r=-0.40,P＜0.01),while the ADOS stereotype score was not significantly related to total IQ(r=-0.10,P=0.20).Conclusion Both the average total IQ and the scores of each functional area of the ASD children are lower than those of the normal children.There are large differences in total IQ among ASD individuals,and gender differences in perceptual reasoning ability.There is no significant difference in ADOS scores among different age groups or gender of children with ASD,thus ongoing support is needed for deficits in social communication and social interaction.There is a negative correlation between core symptoms and IQ in children with ASD.Consequently,interventions should focus on the core deficits of ASD in clinical practice.