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铁死亡在抑郁症中的研究进展OACSTPCD

Research Progress on Ferroptosis in Depression

中文摘要英文摘要

抑郁症是一种常见的且极易复发的精神疾病,其发病机制仍未完全探明.铁死亡是2012年提出的一种新型细胞死亡形式,参与多种损伤和疾病的发生.有研究表明抑郁小鼠模型体内的铁死亡途径明显被激活,而铁死亡抑制剂有助于改善抑郁症状,表明铁死亡可能参与了抑郁症的发生发展.本文将对铁死亡基本特征和可能导致抑郁症的通路进行综述.

Depression is a common and highly recurrent psychiatric disorder,whose pathogenesis has not been fully elucidated.Ferroptosis,a novel form of cell death proposed in 2012,plays a role in various injuries and diseases.Studies have shown that the pathway of ferroptosis is significantly activated in mouse models of depression,and inhibitors of ferroptosis help improve depressive symptoms,suggesting that ferroptosis may be involved in the development of depression.This article will review the basic characteristics of ferroptosis and the pathways that may lead to depression.

万振宇;肖玲;王慧;王高华

武汉大学人民医院精神卫生中心 武汉 430060||湖北省神经精神疾病研究所 武汉 430060

临床医学

抑郁症;铁死亡;发病机制

depression;ferroptosis;pathogenesis

《神经损伤与功能重建》 2024 (004)

227-229 / 3

10.16780/j.cnki.sjssgncj.20220620

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