目的 比较左半结肠癌(LCC)和右半结肠癌(RCC)患者下一代测序基因检测结果和临床病理特征.方法 回顾性收集2022年1月至2023年6月该院分子诊断中心335例结肠癌患者的下一代测序技术基因检测结果及临床病例资料,分析LCC、RCC的分子生物学和临床病理特征.结果 335例患者中LCC 267例,RCC 72例.与LCC患者比较,RCC患者肿瘤最大径≥5 cm占比(44.44％vs.14.83％)及BRAF(8.33％vs.3.04％)、PTEN(12.50％vs.3.80％)、PIK3CA(26.39％vs.10.65％)、SMAD4(16.90％vs.9.47％)基因突变率和微卫星高度不稳定型(MSI-H)占比(13.89％vs.1.52％)更高,TP53基因突变率(66.67％vs.82.51％)更低,差异有统计学意义(P＜0.05).结论 LCC、RCC患者的分子生物学和病理特征存在差异.
Objective To compare the results of the next generation sequencing gene testing and clini-copathological characteristics in the patients with left hemicolon cancer(LCC)and right hemicolon cancer(RCC).Methods The next generation sequencing gene testing results and clinical pathological data of 335 pa-tients with colon cancer in the Molecular Diagnosis Center of this hospital from January 2022 to June 2023 were collected retrospectively.The molecular biological and clinical characteristics of LCC and RCC were ana-lyzed.Results Among 335 patients,263 cases were LCC and 72 cases were RCC.The proportions of tumors maximal diameter ≥5 cm,gene mutation rates of BRAF,PTEN,PIK3CA and SMAD4,and microsatellite in-stability-high(MSI)in the patients with RCC were higher than those in the patients with LCC(44.44％vs.14.83％,8.33％vs.3.04％,12.50％vs.3.80％,26.39％vs.10.65％,16.90％vs.9.47％,13.89％vs.1.52％,P＜0.05),the TP53 gene mutation rate was lower(66.67％vs.82.51％),and the differences were statistically significant(P＜0.05).Conclusion There are differences in molecular biology and pathological characteristics between the patients with LCC and the patient with RCC.
韩婷婷;刘馨;王晓雄;李鸿生;蔡静静;李卓颖;郭银金;杨锐娇;周永春
云南省肿瘤医院/昆明医科大学第三附属医院:分子诊断中心,昆明 650118云南省肿瘤医院/昆明医科大学第三附属医院:云南省肺癌研究重点实验室,昆明 650118云南省肿瘤医院/昆明医科大学第三附属医院:教育部高原区域性高发肿瘤国际合作联合实验室,昆明 650118云南省肿瘤医院/昆明医科大学第三附属医院:云南省肿瘤精准诊疗工程研究中心,昆明 650118
临床医学
左右半结肠癌;二代测序;基因突变;分子生物学特征;临床病理特征
left and right hemicolon cancer;second generation sequencing;gene mutations;molecular biological characteristics;clinical pathological features
《重庆医学》 2024 (007)
1016-1020,1026 / 6
国家自然科学基金项目(81860513);云南省教育厅科学研究基金项目(2023Y0598).
10.3969/j.issn.1671-8348.2024.07.010
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