目的 探讨对消化道出血患者分别采用奥美拉唑、兰索拉唑治疗后获得的临床效果差异.方法 选取2020年3月至2022年8月山东国欣颐养集团枣庄中心医院收治的66例消化道出血患者作为研究对象,采用随机数表法将其分为参照组和研究组,每组各33例.参照组给予奥美拉唑治疗;研究组给予兰索拉唑治疗.比较两组患者的治疗总有效率、血红蛋白水平、血清学炎性因子水平、腹部疼痛缓解时间、止血时间、血压恢复正常时间、心室率恢复正常时间、大便潜血试验转阴时间以及不良反应(皮疹、恶心呕吐)总发生率.结果 研究组患者治疗总有效率高于参照组,差异有统计学意义(P＜0.05).治疗后,研究组患者血红蛋白水平高于参照组,超敏C反应蛋白、肿瘤坏死因子-α、白细胞介素-6水平低于参照组,差异有统计学意义(P＜0.05).研究组患者腹部疼痛缓解时间、止血时间、血压恢复正常时间、心室率恢复正常时间、大便潜血试验转阴时间短于参照组,差异有统计学意义(P＜0.05).两组不良反应总发生率比较,差异无统计学意义(P＞0.05).结论 在消化道出血治疗期间,兰索拉唑可提升患者的治疗效果,有效改善患者血红蛋白、血清学炎性因子水平,显著缩短患者腹部疼痛缓解时间、止血时间、血压恢复正常时间、心室率恢复正常时间、大便潜血试验转阴时间,并且不会增加不良反应的发生率.
Objective To explore the differences in clinical effects of patients with gastrointestinal bleeding treated with omeprazole and lansoprazole,respectively.Methods A total of 66 patients with gastrointestinal bleeding from Shandong Healthcare Group Zaozhuang Central Hospital during the period of March 2020 to August 2022 were selected as the research subjects.The patients were divided into a control group and a study group using a random number table method,with 33 cases in each group.The reference group was treated with omeprazole.The study group was treated with lansoprazole.The total effective rate of treatment,hemoglobin levels,serum inflammatory factor levels,abdominal pain relief time,hemostasis time,time for blood pressure to return to normal,time for ventricular rate to return to normal,time for the fecal occult blood test to be negative,and total incidence of adverse reactions(rash,nausea and vomiting)were compared between the two groups of patients with gastrointestinal bleeding.Results The total effective rate of treatment in patients in the study group was higher than that in the control group,with statistically significant difference(P＜0.05).After the treatment,the hemoglobin levels in patients were higher in the study group than in the control group,and the hypersensitive C-reactive protein levels,tumor necrosis factor-α levels and interleukin-6 levels were lower in the study group than in the control group,with statistically significant differences(P＜0.05).The time for abdominal pain relief,hemostasis,blood pressure return to normal,ventricular rate return to normal,and fecal occult blood test to be negative in the study group were shorter than those in the control group,with statistically significant differences(P＜0.05).The total incidence of adverse reactions was compared between the two groups,without statistically significant difference(P＞0.05).Conclusion During the treatment of gastrointestinal bleeding,lansoprazole can significantly improve the treatment effect,effectively improve the hemoglobin levels and serum inflammatory factor levels,and significantly shorten the abdominal pain relief time,hemostasis time,time for blood pressure to return to normal,time for ventricular rate to return to normal,and time for the fecal occult blood test to be negative,without increasing the incidence of adverse reactions.
管新帅;周侠;陈鹏
山东国欣颐养集团枣庄中心医院药学部,山东枣庄 277000山东国欣颐养集团枣庄中心医院消化内科,山东枣庄 277000
临床医学
奥美拉唑;兰索拉唑;消化道出血;不良反应
Omeprazole;Lansoprazole;Gastrointestinal bleeding;Adverse reactions
《中国医药科学》 2024 (006)
80-83 / 4
10.20116/j.issn2095-0616.2024.06.18
评论