发热伴血小板减少综合征病人实验室检查指标与临床结局的相关性OACSTPCD

Objective To investigate the association between laboratory markers and clinical outcomes in patients with se-vere fever with thrombocytopenia syndrome(SFTS),and to provide a basisfor the clinical diagnosis and treatment of this disease.Methods A retrospective analysis was performed for the clinical data of 100 patients who were hospitalized and had a confirmed-diagnosis of SFTS in Qingdao Sixth People's Hospital,and according to the clinical outcome,they were divided into survival group and death group.The association of laboratory markers with early diagnosis and clinical outcome was analyzed for the two groups.Results There were significant differences between the two groups in viral load,C-reactive protein,procalcitonin(PCT),inter-leukin-6,interleukin-10(IL-10),interferon-γ,alanine aminotransferase,aspartate aminotransferase,gamma-glutamyl transpepti-dase,lactate dehydrogenase,α-hydroxybutyrate dehydrogenase,creatine kinase,creatine kinase isoenzyme,urea nitrogen,creati-nine,prothrombin time,prothrombin activity,activated partial thromboplastin time,D-dimer,CD3+lymphocyte count,CD4+lymphocyte count,CD8+lymphocyte count,and blood Ca2+(Z=2.301-6.043,t=4.393,3.605,P＜0.05).IL-10,PCT,and viral load were independent risk factors for death(OR=1.010-4.801,P＜0.05).Conclusion Multiple laboratory markers can pre-dict the clinical outcome of patients with SFTS,and the elevated levels of IL-10,PCT,and viral load canincrease risk of death in patients.Therefore,early measurementand dynamic observation of multiple laboratory markers can help to guide clinical diagnosis and treatment.