目的:观察平肝清肺汤联合隔物灸对支气管扩张患者痰液体积的影响.方法:选取2021 年1 月至2022 年1 月安远县人民医院治疗的支气管扩张患者90 例作为此次研究对象,根据治疗方法不同分成常规组和试验组各45 例.常规组给予平肝清肺汤治疗,试验组给予平肝清肺汤联合隔物灸治疗.观察两组患者治疗前后中医证候积分、血气分析指标[动脉血氧分压(ar-terial partial pressure of oxygen,PaO2)、血氧饱和度(oxygen saturation of blood,SaO2)、二氧化碳分压(partial pressure of carbon di-oxide,PaCO2)]、炎性介质[肿瘤坏死因子(tumor necrosis factor,TNF)-α、白细胞介素(interleukin,IL)-4、IL-23]水平、痰液体积及液细菌负荷阳性率、莱塞斯特咳嗽生命质量问卷(leicester cough questionnaire,LCQ)总分改善情况.结果:试验组治疗后中医证候积分低于常规组,差异有统计学意义(P<0.05).试验组治疗后PaO2、SaO2 高于常规组,PaCO2 低于常规组,差异有统计学意义(P<0.05).试验组治疗后TNF-α、IL-4、IL-23、痰液体积均低于常规组,差异有统计学意义(P<0.05).试验组液细菌负荷阳性率低于常规组,LCQ总分高于常规组,差异有统计学意义(P<0.05).结论:平肝清肺汤联合隔药灸能够改善支气管扩张患者临床症状,减少患者痰液细菌量,促进肺功能恢复正常.
Objective:To observe the influence of Liver-Calming and Lung-Clearing Decoction combined with interposed moxibustion on sputum volume in patients with bronchiectasis.Methods:A total of 90 patients with bronchiectasis treated in Anyuan People's Hospital from January 2021 to January 2022 were selected as the research subjects,and were divided into the conventional group and the experi-mental group,with 45 cases in each group.The conventional group was given Liver-Calming and Lung-Clearing Decoction,while the ex-perimental group was given Liver-Calming and Lung-Clearing Decoction combined with interposed moxibustion.The improvement of the TCM syndrome scores,blood-qi analysis indexes[including arterial partial pressure of oxygen(PaO2),oxygen saturation of blood(SaO2),partial pressure of carbon dioxide(PaCO2)],inflammatory mediators[including tumor necrosis factor(TNF)-α,interleukin(IL)-4,IL-23]levels,sputum volume and positive rate of bacterial load,and Leicester cough questionnaire(LCQ)total scores of the two groups before and after treatment were observed.Results:After treatment,the TCM syndrome scores of the experimental group were lower than those of the conventional group,with statistically significant differences(P<0.05);the PaO2 and SaO2 of the experimental group were higher than those of the conventional group,while the PaCO2 was lower than that of the conventional group,with statistically significant differences(P<0.05);the levels of TNF-α,IL-4,IL-23 and sputum volume in the experimental group were lower than those of the conventional group,with statistically significant differences(P<0.05).The positive rate of bacterial load in the experimental group was lower than that in the conventional group,while the total score of LCQ was higher than that in the conventional group,with statistically significant differences(P<0.05).Conclusion:Liver-Calming and Lung-Clearing Decoction combined with interposed moxi-bustion can improve the clinical symptoms of patients with bronchiectasis,reduce the amount of bacteria in sputum,and promote the re-covery of lung function.
陈润杉;陈检娣;薛春;谢伟
安远县人民医院,江西 安远 342100
中医学
支气管扩张;平肝清肺汤;隔物灸;痰液体积
bronchiectasis;Liver-Calming and Lung-Clearing Decoction;interposed moxibustion;sputum volume
《河南中医》 2024 (004)
609-613 / 5
江西省中医药管理局科研项目(2020B0132)
10.16367/j.issn.1003-5028.2024.04.0115
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