目的:观察骨坚汤联合利塞膦酸钠片治疗老年骨质疏松症的临床疗效.方法:将 74 例老年骨质疏松症患者运用信封法分为对照组和联合组,每组各37 例.对照组给予利塞膦酸钠片治疗,联合组给予骨坚汤联合利塞膦酸钠片治疗.比较两组患者的临床疗效及治疗前后中医证候积分、骨密度、雌二醇(estradiol,E2)变化情况.结果:两组患者治疗后腰脊刺痛、腰膝酸软和下肢痿弱等中医证候积分低于本组治疗前,且联合组低于照组(P<0.05).两组患者治疗后腰椎L2-4和股骨颈处骨密度高于本组治疗前,且治疗后联合组高于对照组(P<0.05).两组治疗后E2 高于本组治疗前,且治疗后联合组高于对照组(P<0.05).联合组有效率为94.59%,对照组有效率为75.68%,两组患者有效率比较,差异具有统计学意义(P<0.05).结论:骨坚汤联合利塞膦酸钠片治疗老年骨质疏松症疗效确切,可改善患者临床症状,提高骨密度水平,调节雌激素水平.
Objective:To observe the clinical efficacy of Bone-Strengthening Decoction combined with Riserdronate Sodium Tablets on Senile Osteoporosis.Methods:A total of elderly patients with osteoporosis were divided into the control group and the combined group by envelope method,with 37 cases in each group.The control group was treated with Riserdronate Sodium Tablets,while the combined group was treated with Bone-Strengthening Decoction combined with Riserdronate Sodium Tablets.The clinical efficacy,the changes in TCM syndrome scores,bone mineral density,and estradiol(E2)before and after treatment were compared between the two groups.Re-sults:After treatment,the scores of TCM syndromes such as lumbago and ridge prickle,waist and knee soreness and weakness of lower limbs in the two groups were lower than those before treatment,and the above indexes in the combined group were lower than those in the control group(P<0.05);the bone mineral density of lumbar spine L2-4 and femoral neck in the two groups were higher than those before treatment,and the above indexes in the combined group were higher than those in the control group(P<0.05);the E2 in the two groups was higher than that before treatment,and the above index in the combined group was higher than that in the control group(P<0.05).The effective rate of the combined group was 94.59%,while that of the control group was 75.68%,and the difference was statistically significant(P<0.05).Conclusion:Bone-Strengthening Decoction combined with Riserdronate Sodium Tablets has definite curative effect on senile osteoporosis,which can improve the clinical symptoms of patients,enhance the level of bone mineral density,and regulate the level of estrogen.
潘富荣
乐安县中医院,江西 乐安 344300
中医学
老年骨质疏松症;骨坚汤;利塞膦酸钠片;中西医结合疗法
senile osteoporosis;Bone-Strengthening Decoction;Riserdronate Sodium Tablets;integrated traditional Chinese and Western medicine
《河南中医》 2024 (004)
586-590 / 5
10.16367/j.issn.1003-5028.2024.04.0110
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