目的:观察海马补肾壮阳丸治疗肾阳虚型特发性少精子症的临床疗效.方法:将180 例特发性少精子症患者按照随机数字表法分为对照组和治疗组,每组各90 例.治疗组口服海马补肾壮阳丸,对照组口服枸橼酸氯米芬片.比较两组患者的临床疗效、中医证候疗效、配偶妊娠率及治疗前后精子浓度、中医证候积分变化情况;检测两组患者治疗前后血清睾酮(testoster-one,T)、卵泡刺激素(follicle-stimulating hormone,FSH)、黄体生成素(luteinizing hormone,LH)及血清抑制素B(serum inhibin B,INHB)等水平.结果:治疗组有效率为79.55%,对照组有效率为 62.07%,两组患者临床疗效比较,差异具有统计学意义(P<0.05).治疗组有效率为86.36%,对照组有效率为 51.72%,两组患者中医证候疗效比较,差异具有统计学意义(P<0.05).治疗组配偶妊娠率为16.67%,对照组配偶妊娠率为 5.07%,治疗组高于对照组,差异具有统计学意义(P<0.05).两组患者精子浓度高于本组治疗前,且治疗后治疗组高于对照组,差异具有统计学意义(P<0.05).两组患者治疗后T、FSH、LH、INHB水平高于本组治疗前,且治疗后治疗组T、FSH、INHB高于对照组,差异具有统计学意义(P<0.05),两组患者治疗后LH水平比较,差异无统计学意义(P>0.05).两组患者治疗后中医证候积分低于本组治疗前,且治疗后治疗组低于对照组,差异具有统计学意义(P<0.05).结论:海马补肾壮阳丸治疗特发性少精子症,可改善精子浓度及生殖内分泌水平,提高配偶妊娠率.
Objective:To observe the clinical efficacy of Haima Kidney-Nourishing and Yang-Strengthening Pills on idiopathic oligozo-ospermia with syndrome of kidney yang deficiency.Methods:A total of 180 patients with idiopathic oligozoospermia were divided into the control group and the treatment group according to the random number table method,with 90 cases in each group.The treatment group was given Haima Kidney-Nourishing and Yang-Strengthening Pills for oral administration,while the control group was given Clomiphene Citrate Tablets for oral administration.The clinical efficacy,TCM syndrome efficacy,spouse pregnancy rate,sperm concentration and TCM syndrome score changes before and after treatment were compared between the two groups.The levels of serum testosterone(T),follicle-stimulating hormone(FSH),luteinizing hormone(LH)and serum inhibin B(INHB)were detected before and after treatment in the two groups.Results:In terms of clinical efficacy,the effective rate of the treatment group was 79.55%,while that of the control group was 62.07%,with a statistically significant difference(P<0.05).In terms of TCM syndrome efficacy,the effective rate of the treatment group was86.36%,while that of the control group was 51.72%,with a statistically significant difference(P<0.05).The pregnancy rate of the spouse in the treatment group was 16.67%,while that in the control group was 5.07%,the treatment group's pregnancy rate was higher than that of the control group,with a statistically significant difference(P<0.05).The sperm concentration of the two groups was higher than that before treatment,and the treatment group's was higher than that of the control group after treat-ment,with a statistically significant difference(P<0.05).The levels of T,FSH,LH,and INHB in the two groups after treatment were higher than those of the same group before treatment,while the T,FSH,and INHB in the treatment group were higher than those in the control group after treatment,and all the differences were statistically significant(P<0.05).There was no statistically significant difference in the level of LH between the two groups after treatment(P>0.05).The TCM syndrome scores of the two groups after treat-ment were lower than those before treatment,and the treatment group's scores were lower than those of the control group after treatment,and the difference was statistically significant(P<0.05).Conclusion:Haima Kidney-Nourishing and Yang-Strengthening Pills for idio-pathic oligozoospermia can improve sperm concentration and reproductive endocrine levels,enhance the pregnancy rate of the spouse,and relieve clinical symptoms.
门波;胡创政;高鹏飞;付晓君
河南省中医院,河南中医药大学第二附属医院,河南 郑州 450002河南中医药大学,河南 郑州 450046河南张仲景大药房,河南 郑州 450002
中医学
海马补肾壮阳丸;特发性少精子症;肾阳虚证;枸橼酸氯米芬片
Haima Kidney-Nourishing and Yang-Strengthening Pills;idiopathic oligozoospermia;syndrome of kidney yang deficiency;Clomiphene Citrate Tablets
《河南中医》 2024 (004)
556-560 / 5
河南省中医药科学研究专项课题(20-21ZY2052);河南省第二批中医药青苗人才培养计划项目{豫卫中医函[2021]16}
10.16367/j.issn.1003-5028.2024.04.0104
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