不同剂量珂立苏治疗重症新生儿呼吸窘迫综合征的对照研究OA

Objective To explore the value of different doses of Calsurf in the treatment of severe neonatal respiratory distress syndrome(NRDS).Methods A total of 126 children with severe NRDS treated in the neonatal intensive care unit of Lianjiang People's Hospital from January 2020 to June 2023 were divided into groups A,B,and C by random table method.Groups A,B,and C were given 70 mg/kg,100 mg/kg,and 140 mg/kg of Calsurf,respectively.The blood gas indicators,treatment status,hospitalization costs,length of stay,and complications among the three groups were compared.Results Compared with Group A,Group B and Group C had significantly lower arterial carbon dioxide partial pressure,a ratio of≥2 times of use of Calsurf,laboratory expenses,treatment expenses,and nursing expenses after 6 hours of treatment.The arterial oxygen partial pressure and oxygenation index were significantly higher after 6 hours of treatment,and the time for auxiliary ventilation,oxygen therapy,and total hospitalization were significantly shorter,with statistically significant differences(P<0.05).The drug and total hospitalization expenses were the lowest in Group B,followed by Group C,and the highest in Group A,with statistically significant differences(P<0.05).Conclusion 100 mg/kg Calsurf can reduce medication costs and total hospitalization expenses in the treatment of severe NRDS.The treatment of NRDS with 100 mg/kg and 140 mg/kg Calsurf is superior to 70 mg/kg Calsurf in improving blood gas indicators,reducing the frequency of Calsurf medication,shortening auxiliary ventilation time,oxygen therapy time,and hospital stay.