NOD样受体家族中的NLRP3 蛋白小体是先天免疫系统的一个重要组成部分,其可被多种刺激激活,包括离子通量、线粒体功能障碍、活性氧的产生和溶酶体损伤,通过介导含半胱氨酸的天冬氨酸蛋白水解酶-1(caspase-1)激活及促炎细胞因子白细胞介素-1β(IL-1β)和白细胞介素-18(IL-18)的分泌,从而导致各种类型的细胞焦亡.在眼科疾病中,很多发病机制及其激活方式目前尚未清楚,但通过对NLRP3 炎症小体的研究探索,使年龄相关性黄斑变性、糖尿病视网膜病变、干眼症、青光眼等疾病的发病过程和机制更加清晰.现就NLRP3 炎症小体的生物学特征及其激活和调控机制,及其对相关眼部疾病的关系和最新研究现状做一综述.
The NLRP3 proteome in the NOD-like receptor family is an important component of the innate immune system,which can be activated by various stimuli,including ion fluence,mitochondrial dysfunction,production of reactive oxygen species,and lysosomal damage.They mediate the activation of cysteine-containing aspartate proteolytic enzyme-1(caspase-1)and the secretion of the pro-inflammatory cytokine interleukin-1β(IL-1β)and interleukin-18(IL-18),leading to various cell death.In ophthalmic diseases,the pathogenesis and activation mode of many diseases are not yet clear,but through the research and exploration of NLRP3 inflammasome,the pathogenesis and mechanism of age-related macular degeneration,diabetic retinopathy,dry eye,glaucoma,and other diseases are clearer.This article reviews the biological characteristics and activation and regulatory mechanisms of NLRP3 inflammasomes,their relationship with related eye diseases,and the latest research status.
许嘉洋;张天资;樊世超
内蒙古民族大学临床医 (蒙医)学院,内蒙古通辽 028000内蒙古民族大学附属医院眼科,内蒙古通辽 028000湖北省十堰市人民医院眼科,湖北十堰 442000
临床医学
NLRP3;眼科疾病;含半胱氨酸的天冬氨酸蛋白水解酶-1;白细胞介素-1β
NLRP3;Ophthalmic diseases;Caspase-1;Interleukin-1β
《中国医药科学》 2024 (005)
42-45 / 4
内蒙古自治区卫生健康科技计划项目(202201471).
10.20116/j.issn2095-0616.2024.05.09
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