NF-κB信号通路在儿童支气管哮喘中的研究进展OA

Childhood bronchial asthma is a chronic inflammatory disease characterized by extensive airflow obstruction.Currently,its pathogenesis is not yet clear and may involve inflammation,immunity,airway remodeling,etc.,involving nuclear factor-kappa B(NF-κB)signaling pathway.At present,the main treatment focus is on controlling asthma attacks and delaying the further development of the condition.The main drugs such as hormones etc.are used for symptomatic treatments,which cannot eradicate the disease and may have a serious impact on children.Researchers hope to provide a new target for clinical diagnosis and treatment of NF-κB by exploring the specific pathogenesis of bronchial asthma in children.This article reviews the mechanism of NF-κB signaling pathway in the pathogenesis of bronchial asthma in children,and provides theoretical guidance for subsequent studies.