目的 探讨慢性肾衰竭并心衰患者运用连续性肾脏替代治疗方案的效果.方法 选取武威市凉州医院 2022 年 1 月至 2023 年 1 月收治的慢性肾衰竭并心衰患者 80 例,采用随机数表法分为两组,每组各 40例,对照组运用血液透析治疗方案,观察组运用连续性肾脏替代治疗方案.比较两组总有效率、肾功能指标、心功能指标、炎症因子指标及不良反应发生率.结果 观察组总有效率为 97.50%,高于对照组的 82.50%,差异有统计学意义(P<0.05).治疗后,观察组肾功能指标即尿素氮(BUN)、血肌酐(Scr)、半胱氨酸蛋白酶抑制剂(Cys-C)低于对照组,差异有统计学意义(P<0.05).治疗后,观察组心功能指标即左室射血分数(LVEF)高于对照组,左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)低于对照组,差异有统计学意义(P<0.05).治疗后,观察组炎性因子指标即C反应蛋白(CRP),白细胞介素-6(IL-6)、降钙素原(PCT)低于对照组,差异有统计学意义(P<0.05).观察组不良反应总发生率低于对照组,差异有统计学意义(P<0.05).结论 慢性肾衰竭并心衰患者采用连续性肾脏替代治疗方案可提高总有效率,改善肾功能、心功能,降低炎症反应程度,且具有更高安全性.
Objective To explore the effectiveness of continuous renal replacement therapy in patients with chronic renal failure and heart failure.Methods A total of 80 patients with chronic renal failure and heart failure admitted to Wuwei Liangzhou Hospital from January 2022 to January 2023 were selected.They were divided into two groups using a random number table method,with 40 patients included in each group.The control group received hemodialysis therapy,while the observation group received continuous renal replacement therapy.The total effective rate,renal function indicators,cardiac function indicators,inflammatory factor indicators,and adverse reaction rates were compared between the two groups.Results The total effective rate of the observation group was 97.50%,which was higher than the control group's 82.50%,with statistically significant differences(P<0.05).After treatment,the renal function indicators of the observation group,including blood urea nitrogen(BUN),serum creatinine(Scr),and cysteine C(Cys-C)inhibitor,were lower than those of the control group,with statistically significant differences(P<0.05).After treatment,the left ventricular ejection fraction(LVEF)of the observation group was higher than that of the control group,while the left ventricular end diastolic diameter(LVEDD)and left ventricular end systolic diameter(LVESD)were lower than those of the control group,with statistically significant differences(P<0.05).After treatment,the inflammatory factor indicators of C-reactiveprotein(CRP),interleukin-6(IL-6)and procalcitonin(PCT)in the observation group were lower than those in the control group,with statistically significant differences(P<0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group,with statistically significant differences(P<0.05).Conclusion Continuous renal replacement therapy for patients with chronic renal failure and heart failure can improve the overall effective rate,improve renal and cardiac function,reduce the degree of inflammatory response,and has higher safety.
王淑萍;李凌霄
甘肃省武威市凉州医院重症医学科,甘肃武威 733000
临床医学
慢性肾衰竭并心衰;连续性肾脏替代;肾功能;心功能;不良反应
Chronic renal failure with heart failure;Continuous renal replacement;Renal function;Cardiac function;Adverse reactions
《中国医药科学》 2024 (005)
195-198 / 4
10.20116/j.issn2095-0616.2024.05.45
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