目的 分析肺癌早期诊断中应用血清神经元特异性烯醇化酶(NSE)、细胞角蛋白 19 片段(CYFRA21-1)、癌胚抗原(CEA)、鳞状上皮细胞癌抗原(SCC)联合检测的临床价值.方法 选择2021年1 月至2022 年 12 月阳江市中医医院收治的肺癌患者 70 例(肺癌组)、肺部良性病变患者 64 例(良性组),并同期选择体检健康人员 70 名(对照组)进行回顾性分析,所有受检者均接受血清NSE、CYFRA21-1、CEA、SCC检测,分析三组受检者检查结果,并分析血清标志物的诊断敏感度、特异度及准确度.结果 肺癌组患者血清NSE、CEA、CYFRA21-1、SCC指标均高于对照组与良性组,差异有统计学意义(P<0.05);依据不同病理分型将肺癌组患者 70 例分为小细胞癌患者 29 例、非小细胞肺癌患者 41 例,非小细胞肺癌患者CEA、CYFRA21-1、SCC均高于小细胞癌患者,且NSE低于小细胞癌患者,差异有统计学意义(P<0.05);联合诊断的敏感度及准确度均高于单一检查,差异有统计学意义(P<0.05).结论 对于肺癌患者而言,早期使用血清NSE、CYFRA21-1、CEA、SCC联合检测具有积极意义,其能有效提高诊断的敏感度及准确度,为临床医生提供可靠的参考.
Objective To analyze the clinical value of combined testing of serum neuron specific enolase(NSE),cytokeratin-19-fragment(CYFRA21-1),carcinoembryonic antigen(CEA),and squamous cell carcinoma antigen(SCC)in the early diagnosis of lung cancer.Methods A total of 70 patients with lung cancer(the lung cancer group)and 64 patients with benign lung lesions(the benign group)admitted to Yangjiang Hospital of Traditional Chinese Medicine from January 2021 to December 2022,and 70 healthy physical examiners(the control group)during the same period were selected for retrospective analysis.All subjects received serum NSE,CYFRA21-1,CEA,and SCC tests.The test results of the three groups of subjects were analyzed,and the diagnostic sensitivity,specificity,and accuracy of serum markers were analyzed.Results The serum NSE,CEA,CYFRA21-1,and SCC indicators in the lung cancer group were higher than those in the control group and the benign group(P<0.05).According to different pathological classifications,70 patients in the lung cancer group were divided into 29 cases of small cell carcinoma and 41 cases of non-small cell lung cancer.CEA,CYFRA21-1,and SCC in patients with non-small cell carcinoma were higher than those in patients with small cell carcinoma,and NSE were lower than those in patients with small cell carcinoma,with statistically significant differences(P<0.05).The sensitivity and accuracy of combined diagnosis were higher than those of single test,with statistically significant differences(P<0.05).Conclusion For patients with lung cancer,early use of combined testing of serum NSE,CYFRA21-1,CEA,and SCC has a positive significance,which can effectively improve the sensitivity and accuracy of diagnosis,providing reliable reference for clinical doctors.
洪永灯;黄旭苗
广东省阳江市中医医院检验科,广东阳江 529500广东省阳江市中医医院中药房,广东阳江 529500
临床医学
肺癌;早期诊断;联合检测;血清肿瘤标志物
Lung cancer;Early diagnosis;Combined testing;Serum tumor markers
《中国医药科学》 2024 (005)
157-160 / 4
10.20116/j.issn2095-0616.2024.05.36
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