目的 探析在直肠癌化疗患者中磁共振T2 加权图像纹理分析的应用情况.方法 本研究选取山东省立医院 2019 年 6 月至 2022 年 10 月收治的 116 例经过手术治疗的直肠癌患者作为研究对象,所有患者均接受病理学检查和临床检查,以确定其诊断结果.根据缓解与否分为非完全缓解组(n=75)、完全缓解组(n=41).治疗前后对患者开展磁共振扫描;应用Omni Kineitics软件对患者纹理特征提取并计算能量参数和方差、峰度和熵.利用ROC曲线对磁共振T2 加权图像纹理分析,对直肠癌化疗后病理完全缓解情况进行评估.结果 治疗后,非完全缓解组的能量参数为(0.03±0.01)、峰度为(3.71±0.50),均低于完全缓解组的(0.05±0.01)、(4.84±0.67)(P<0.05);非完全缓解组的方差为(2311.00±587.00)、熵为(6.41±0.30),均高于完全缓解组的(1533.00±313.00)、(5.42±0.42)(P<0.05).完全缓解组中,磁共振扫描纹理分析方差与熵的关系呈负相关(P<0.05),和峰度、能量的关系呈正相关(P<0.05).磁共振扫描纹理的能量参数、方法、峰度和熵的特异度、敏感度均≥85%,AUC均≥0.85.结论 通过使用磁共振T2 加权图像纹理分析,临床可以更准确地评估直肠癌患者接受化疗治疗后的病理状态,从而更好地预测其完全缓解情况.
Objective To explore the application of magnetic resonance T2 weighted image texture analysis in rectal cancer patients undergoing chemotherapy.Methods This study used 116 surgically treated rectal cancer patients who underwent surgical treatment and were admitted to Shandong Provincial Hospital from June 2019 to October 2022 as the research subjects,and they all underwent pathological examination and clinical examination to determine their diagnostic results.They were grouped according to response or not,namely non-complete response group(n=75)and complete response group(n=41).Magnetic resonance imaging was performed on patients before and after chemotherapy;Omni Kinetics software was applied to extract patient texture features,and energy parameters and variance,kurtosis,and entropy were calculated.ROC curve was used for texture analysis of magnetic resonance T2 weighted images to evaluate the pathological complete response of rectal cancer after chemotherapy.Results After treatment,the energy parameters(0.03±0.01)and kurtosis(3.71±0.50)of the non-complete response group were lower than those of the complete response group(0.05±0.01)and(4.84±0.67)(P<0.05).The variance(2311.00±587.00)and entropy(6.41±0.30)of the non-complete response group were higher than those of the complete response group(1533.00±313.00)and(5.42±0.42)(P<0.05).In the complete response group,the variance of magnetic resonance scanning texture analysis was negatively correlated with entropy(P<0.05),and positively correlated with kurtosis and energy(P<0.05).The specificity and sensitivity of energy parameters,methods,kurtosis and entropy of magnetic resonance scanning texture were not less than 85%,and the AUC was not less than 0.85.Conclusion By using MR T2 weighted image texture analysis,clinical practice can more accurately assess the pathological status of rectal cancer patients after chemotherapy treatment and thus better predict their complete response.
苑乐添
山东省立医院放射科,山东济南 250021
临床医学
直肠癌;T2加权图像;磁共振;纹理分析;病理完全缓解
Rectal cancer;T2 weighted image;Magnetic resonance;Texture analysis;Complete pathological response
《中国医药科学》 2024 (005)
153-156,160 / 5
10.20116/j.issn2095-0616.2024.05.35
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